Abstract
Drug plasma levels of N-desmethyldiazepam (10 and 20 mg/day given at night) and amylobarbitone sodium (200 mg/day given at night) were determined in 45 patients after 1 and 7 days of treatment together with estimates of hypnotic and residual effects. No relationships were found between clinical ratings of hypnotic effect and drug plasma levels, while significant correlations were observed between some performance tasks and drug plasma concentrations of amylobarbitone sodium, and of the higher dose of N-desmethyldiazepam.
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Tansella, M., Siciliani, O., Burti, L. et al. N-desmethyldiazepam and amylobarbitone sodium as hypnotics in anxious patients. Plasma levels, clinical efficacy and residual effects. Psychopharmacologia 41, 81–85 (1975). https://doi.org/10.1007/BF00421061
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DOI: https://doi.org/10.1007/BF00421061