The effect of acute and repeated δ 8-THC administration on alcohol-induced sleeping time was studied in male albino rats. We have observed that acute pretreatment with δ 8-THC markedly potentiates alcohol-induced sleeping time in a dose-related manner. This potentiation of the alcohol sleeping time is shortened significantly after repeated prior treatment with δ 8-THC and can be observed 72 hrs post-chronic treatment. The effect of δ 8-THC on alcohol-induced sleeping time is not associated with an altered alcohol metabolism rate.
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Friedman, E., Gershon, S. Effect of δ8-THC on alcohol-induced sleeping time in the rat. Psychopharmacologia 39, 193–198 (1974). https://doi.org/10.1007/BF00421026
- Acute and Chronic δ 8-THC
- Sleeping Time