Abstract
We report a mapping and linkage disequilibrium analysis of six restriction fragment length polymorphisms (RFLPs) of the human fibronectin gene. The polymerase chain reaction conditions are described for four of the RFLPs.
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Colombi M, Gardella R, Barlati S, Vaheri A (1987) A frequent HaeIII RFLP of the human fibronectin gene. Nucleic Acids Res 15:6761
Colombi M, Gardella R, Barlati S (1988) A frequent HindIII RFLP of the human fibronectin gene (FN1). Nucleic Acids Res 16:9074
Gardella R, Colombi M, Barlati S (1988a) A common MspI RFLP of the human fibronectin gene (FN1). Nucleic Acids Res 16:1651
Gardella R, Colombi M, Barlati S (1988b) A TaqI RFLP for the human fibronectin (FN1) gene. Nucleic Acids Res 16:11388
Gardella R, Colombi M, Barlati S (1989) A new TaqI RFLP of the human fibronectin (FN1) gene. Nucleic Acids Res 17:10520
Jhanwar SC, Jensen JT, Kaelbling M, Chaganti RSK, Klinger HP (1986) In situ localization of human fibronectin (FN) genes to chromosome regions 2p14-p16, 2q34-36, and 11q12.1-q13.5in germ line cells, but to chromosome 2 sites only in somatic cells. Cytogenet Cell Genet 41:47–53
Kornblihtt AR, Umezawa K, Vibe-Pedersen K, Baralle FE (1985) Primary structure of human fibronectin: differential splicing may generate at least 10 polypeptides from a single gene. EMBO J 4:1755–1759
Litt M, Jorde LB (1986) Linkage disequilibria between pairs of loci within a highly polymorphic region of chromosome 2Q. Am J Hum Genet 39:166–178
Lobos EA, Rudnick CH, Watson MS, Isenberg KE (1989) Linkage disequilibrium study of RFLPs detected at the human muscle nicotinic acetylcholine receptor subunit genes. Am J Hum Genet 44:522–533
MacLean CJ, Morton NE (1985) Estimation of myriad haplotype frequencies. Genet Epidemiol 2:263–272
Thompson EA, Deeb S, Walker D, Motulsky AG (1988) The detection of linkage disequilibrium between closely linked markers: RFLPs at the AI-CIII apolipoprotein genes. Am J Hum Genet 42:113–124
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Gardella, R., Colombi, M. & Barlati, S. Human fibronectin gene (FN1) RFLPs: Mapping and linkage disequilibrium analysis. Hum Genet 92, 639–641 (1993). https://doi.org/10.1007/BF00420958
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DOI: https://doi.org/10.1007/BF00420958