Abstract
A new polymorphism has been identified in the 3′-untranslated region of the gene for GAP43. It is present with a frequency of 0.327 in the Centre d'Etude du Polymorphisme Humaine (CEPH) parents and is slightly lower in Alzheimer's (0.269) and Parkinson's (0.231) patients.
Similar content being viewed by others
References
Dausset J, Cann H, Cohen D, Lathrop M, Lalouel JN, White R (1990) Collaborative genetic mapping of the human genome. Genomics 6:676–677
Gispen WH, Nielander P, De Graan PNE, Oestreicher AB, Schrama LH, Schotman P (1991) Role of the growth-associated protein B-50/GAP-43 in neuronal plasticity. Mol Neurobiol 5:61–85
Hayashi K (1991) PCR-SSCP: a simple and sensitive method for detection of mutations in the genomic DNA. In: PCR methods, and applications. Cold Spring Harbor Press, pp 34–38
Kosik KS, Orecchio LD, Bruns GAP, Benowitz LI; MacDonald GP, Cox DR, Neve RL (1988) Human GAP-43: Its deduced amino acid sequence and chromosomal localization in mouse and human. Neuron 1:127–132
Lowe T, Sharefkin J, Yang SQ, Dieffenbach CW (1990) A comuter program for selection of oligonucleotide primers for polymerase chain reactions. Nucleic Acids Res 18:1757–1761
Poduslo SE, Dean M, Kolch U, O'Brien SJ (1991) Detecting highresolution polymorphisms in human coding loci by combining PCR and single-strand conformation polymorphism (SSCP) analysis. Am J Hum Genet 49:106–111
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Poduslo, S.E. A new polymorphism in the gene for GAP43. Hum Genet 92, 635–636 (1993). https://doi.org/10.1007/BF00420956
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00420956