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A new polymorphism in the gene for GAP43

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Abstract

A new polymorphism has been identified in the 3′-untranslated region of the gene for GAP43. It is present with a frequency of 0.327 in the Centre d'Etude du Polymorphisme Humaine (CEPH) parents and is slightly lower in Alzheimer's (0.269) and Parkinson's (0.231) patients.

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References

  • Dausset J, Cann H, Cohen D, Lathrop M, Lalouel JN, White R (1990) Collaborative genetic mapping of the human genome. Genomics 6:676–677

    Google Scholar 

  • Gispen WH, Nielander P, De Graan PNE, Oestreicher AB, Schrama LH, Schotman P (1991) Role of the growth-associated protein B-50/GAP-43 in neuronal plasticity. Mol Neurobiol 5:61–85

    Google Scholar 

  • Hayashi K (1991) PCR-SSCP: a simple and sensitive method for detection of mutations in the genomic DNA. In: PCR methods, and applications. Cold Spring Harbor Press, pp 34–38

  • Kosik KS, Orecchio LD, Bruns GAP, Benowitz LI; MacDonald GP, Cox DR, Neve RL (1988) Human GAP-43: Its deduced amino acid sequence and chromosomal localization in mouse and human. Neuron 1:127–132

    Google Scholar 

  • Lowe T, Sharefkin J, Yang SQ, Dieffenbach CW (1990) A comuter program for selection of oligonucleotide primers for polymerase chain reactions. Nucleic Acids Res 18:1757–1761

    Google Scholar 

  • Poduslo SE, Dean M, Kolch U, O'Brien SJ (1991) Detecting highresolution polymorphisms in human coding loci by combining PCR and single-strand conformation polymorphism (SSCP) analysis. Am J Hum Genet 49:106–111

    Google Scholar 

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Poduslo, S.E. A new polymorphism in the gene for GAP43. Hum Genet 92, 635–636 (1993). https://doi.org/10.1007/BF00420956

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  • DOI: https://doi.org/10.1007/BF00420956

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