Molecular and Cellular Biochemistry

, Volume 64, Issue 1, pp 5–13 | Cite as

Is there a higher level genetic code that directs evolution?

  • Lynn Helena Caporale
Current Thinking


Because the genetic code is redundant for most amino acids, different codons can be used in a given position without altering the structure of the protein for which the gene codes. This flexibility permits information encoding structural, and therefore functional, properties of RNA and DNA to be transmitted simultaneously by a protein-coding sequence of DNA. Among the other messages that might be transmitted, it is proposed, is one modulating the evolution of the DNA itself.


Codon Gene Code Genetic Code 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Grosjean H: In: Schimmel P, Sell P, Abelson J (eds), Transfer RNA. Cold Spring Harbor Monographs, pp 1565–1569,1980.Google Scholar
  2. 2.
    Wilson JT, Wilson JB, Reddy JB, Cavallesco C, Ghosh PK, DeRiel JK, Forget BG, Weissman SM: J Biol Chem 255:2807–2815, 1980.Google Scholar
  3. 3.
    Perler F, Efstratiadis A, Lomedico P, Gilbert W, Kolodner R, Dodgson J: Cell 20:556–566, 1980.Google Scholar
  4. 4.
    Efstratiadis A, Kafatos FC, Maniatis T: Cell 10:571–585, 1977.Google Scholar
  5. 5.
    Tate V, Finer M, Boedtker H, Doty P: Cold Spring Harbor Symp Quant Biol 47:1039–1049, 1982.Google Scholar
  6. 6.
    Sanger F, Air G, Barrell B, Brown N, Coulson AR, Fiddes JC, Hutchison A III, Slocombe PM, Smith M: Nature 265:687–695, 1977.Google Scholar
  7. 7.
    Fiers W, Contreras R, Duerinck F, Haegeman G, Iserentant D, Merregaert J, Min Jon W, Molemans F, Raeymakders A, Van den Berghe A, Volckaert G, Ysebaert M: Nature 260:500–507, 1976.Google Scholar
  8. 8.
    Modiano G, Battistuzzi G, Motulsky AG: Proc Natl Acad Sci USA 78:1110–1114, 1981.Google Scholar
  9. 9.
    Lipman DJ, Wilbur WJ: J Mol Biol 163:363–376, 1983.Google Scholar
  10. 10.
    Grantham R, Gautier C, Gouy M, Jacobzone M, Mercier R: Nucl Acids Res 9:r43-r74, 1981.Google Scholar
  11. 11.
    Crick FHC: J Mol Biol 38:367–379, 1968.Google Scholar
  12. 12.
    Woese CR: J Mol Biol 43:235–240, 1969.Google Scholar
  13. 13.
    Ikemura T, Ozeki H: Cold Spring Harbor Symp Quant Biol 47:1087–1097, 1982.Google Scholar
  14. 14.
    Sanger F: Science 214:1205–1210, 1981.Google Scholar
  15. 15.
    Sackstein, R, Colten HR, Woods DE: J Biol Chem 258:14693–14697, 1983.Google Scholar
  16. 16.
    Reyes AA, Schold M, Wallace RB: Immunogenetics 16:1–9, 1982.Google Scholar
  17. 17.
    Alff-Steinberger C: Proc Natl Acad Sci USA 64:584–591, 1969.Google Scholar
  18. 18.
    Goodman M, Moore GW, Matsuda G: Nature 253:603–608, 1975.Google Scholar
  19. 19.
    Kimura M, Ohta T: Proc Natl Acad Sci USA 71:2848–2852, 1974.Google Scholar
  20. 20.
    Efstratiadis A, Posakony JW, Maniatis T, Lawn RM, O'Connell C, Spritz RA, DeRiel JK, Forget BG, Weissman SM, Slightom JL, Blechl AE, Smithies O, Baralle FE, Shoulders CC, Proudfoot NJ: Cell 21:653–668, 1980.Google Scholar
  21. 21.
    Kvist S, Roberts L, Dobberstein B: EMBO J 2:245–254, 1983.Google Scholar
  22. 22.
    Bothwell ALM, Paskind M, Reth M, Imanishi-Kari T, Rajewsky K, Baltimore D: Cell 24:625–637, 1981.Google Scholar
  23. 23.
    Schreier PH, Bothwell ALM, Mueller-Hill B, Baltimore D: Proc Natl Acad Sci USA 78:4495–4499, 1981.Google Scholar
  24. 24.
    Jung A, Sippel AE, Grez M, Schutz G: Proc Natl Acad Sci USA 77:5759–5763, 1980.Google Scholar
  25. 25.
    Breathnach R, Chambon P: Ann Rev Biochem 50:349–383, 1981.Google Scholar
  26. 26.
    Lerner MR, Boyle JA, Mount N, Wolin SL, Steitz SA: Nature 283:220–224, 1980.Google Scholar
  27. 27.
    Waring RB, Scazzocchio TA, Brown TA, Davies RW: J Mol Biol 167:595–605, 1983.Google Scholar
  28. 28.
    Orkin SH, Kazazian Jr HH, Antonarakis SE, Ostrer H, Goff SC, Sexton JP: Nature 300:768–769, 1982.Google Scholar
  29. 29.
    Wall R., Choi E, Carter C, Kuehl M, Rogers J: Cold Spring Harbor Symp Quant Biol 45:879–885, 1980.Google Scholar
  30. 30.
    Bruijn MHL de: Nature 304:234–241, 1983.Google Scholar
  31. 31.
    Min Jou W, Fiers W: J Mol Biol 106:1047–1060, 1976.Google Scholar
  32. 32.
    Hasegawa M, Yasunaga T, Miyata T: Nucl Acids Res 7:2073–2079, 1979.Google Scholar
  33. 33.
    Kafatos FC, Efstratiadis A, Forget BG, Weissman SM: Proc Natl Acad Sci USA 74:5618–5622, 1977.Google Scholar
  34. 34.
    Watson JD, Crick FHC: Nature 171:964–967, 1953.Google Scholar
  35. 35.
    Dickerson R, Drew H, Conner B, Wing R, Fratini A, Kopka M: Science 216:475–485, 1982.Google Scholar
  36. 36.
    Khoury G., Gruss P: Cell 33:313–314, 1983.Google Scholar
  37. 37.
    Shen C-KJ, Maniatis T: Proc Natl Acad Sci USA 77:6634–6638, 1980.Google Scholar
  38. 38.
    Rich A: Cold Spring Harbor Symp Quant Biol 47:1–12, 1982.Google Scholar
  39. 39.
    Busslinger M, Hurst J, Flavell RA: Cell 34:197–206, 1983.Google Scholar
  40. 40.
    Rogers J, Wall R: Proc Natl Acad Sci USA 78:7497–7501, 1981.Google Scholar
  41. 41.
    Dickerson R: J Mol Biol 166:419–441, 1983.Google Scholar
  42. 42.
    Calladine CR: J Mol Biol 161:343–352, 1982.Google Scholar
  43. 43.
    Haniford DB, Pulleyblank DE: Nature 302:632–634, 1983.Google Scholar
  44. 44.
    Zuckerkandl E: Biochimie 56:937–954, 1974.Google Scholar
  45. 45.
    Lewin R: Science 214:1334–1335, 1981.Google Scholar
  46. 46.
    Pays E, Assel S van, Laurent M, Dero B, Michiels F, Kronenberger O, Matthyssens G, Meirvenne N van, Le Ray D, Steinert M: Cell 34:359–369, 1983.Google Scholar
  47. 47.
    Jennings PA, Finch JT, Winter G, Robertson JS: Cell 34:619–627, 1983.Google Scholar
  48. 48.
    Callan HG: J Cell Sci 2:1–7, 1967.Google Scholar
  49. 49.
    Whitehouse HLK: J Cell Sci 2:9–22, 1967.Google Scholar
  50. 50.
    Geider K, Hoffman-Berling H: Ann Rev Biochem 50:233–60, 1981.Google Scholar
  51. 51.
    Hentschel CC: Nature 295:714–716, 1982.Google Scholar
  52. 52.
    Albertini A, Hofer M, Calos M, Miller J: Cell 29:319–328, 1982.Google Scholar
  53. 53.
    Todd PA, Glickman BW: Proc Natl Acad Sci USA 79:4123–4127, 1982.Google Scholar
  54. 54.
    Ripley LS: Proc Natl Acad Sci USA 79:4128–4132, 1982.Google Scholar
  55. 55.
    Irani M, Oros L, Adhya S: Cell 32:783, 1983.Google Scholar
  56. 56.
    Simons R, Hoopes B, McClure W, Kleckner N: Cell 34:673–682, 1983.Google Scholar
  57. 57.
    Calos M, Miller J: Cell 20:579–595, 1980.Google Scholar
  58. 58.
    Tonegawa S: Nature 302:575–581, 1983.Google Scholar
  59. 59.
    Early P, Huang H, Davis M, Calame K, Hood L: Cell 19:981–992, 1980.Google Scholar
  60. 60.
    Simon M, Zieg J, Silverman M, Mandel G, Doolittle R: Science 209:1370–1374, 1980.Google Scholar
  61. 61.
    Liu AY, Ploeg LHT van der, Rijsewijk FA, Borst P: J Mol Biol 167:57–75, 1983.Google Scholar
  62. 62.
    Nikaido T, Yamawaki-Kataoka Y, Honjo T: J Biol Chem 257:7322–7329, 1982.Google Scholar
  63. 63.
    Shen S, Slightom JL, Smithies O: Cell 26:191–203, 1980.Google Scholar
  64. 64.
    Slightom JL, Blechl AE, Smithies O: Cell 21:627–638, 1980.Google Scholar
  65. 65.
    Cohen JB, Effron K, Rechavi G, Ben-Neriah Y, Zakut R, Givol D: Nucl Acids Res 10:3353–3370, 1982.Google Scholar
  66. 66.
    Hilschmann N, Craig L: Proc Natl Acad Sci USA 53:1403–1409, 1965.Google Scholar
  67. 67.
    Walsh K, Neurath H: Proc Natl Acad Sci USA 52:884–889, 1964.Google Scholar
  68. 68.
    Greer J: J Mol Biol 153:1027–1042, 1981.Google Scholar
  69. 69.
    Furie B, Bing D, Feldmann R, Robison D, Burnier J, Furie B: J Biol Chem 257:3875–3882, 1982.Google Scholar
  70. 70.
    Caporale L., Feldmann R, Bing D: In preparation.Google Scholar
  71. 71.
    Bode W, Chen Z, Bartels K, Kutzbach C, Schmidt-Kastner G, Bartunik HJ: J Mol Biol 164:237–282, 1983.Google Scholar
  72. 72.
    Rodakis GC, Kafatos FC: Proc Natl Acad Sci USA 79:3551–3555, 1982.Google Scholar
  73. 73.
    Blake CCF: Nature 277:598, 1979.Google Scholar
  74. 74.
    Tonegawa S, Maxam A, Tizard R, Barnard O, Gilbert W: Proc Natl Acad Sci USA 75:1485–1489, 1978.Google Scholar
  75. 75.
    Ellison J, Hood L: Proc Natl Acad Sci USA 79:1984–1988, 1982.Google Scholar
  76. 76.
    Craik CS, Rutter WJ, Fletterick R: Science 220:1125–1129, 1983.Google Scholar
  77. 77.
    Yamawaki-Kataoka Y, Miyata T, Honjo T: Nucl Acids Res 9:1365–1381, 1981.Google Scholar
  78. 78.
    Tucker PW, Slightom KL, Blattner FR: Proc Natl Acad Sci USA 78:7684–7688, 1981.Google Scholar
  79. 79.
    Craik CS, Sprang S, Fletterick R, Rutter W: Nature 299:180–182, 1982.Google Scholar
  80. 80.
    Seidman JG, Leder A, Nan M, Norman B, Leder P: Science 202:11–17, 1978.Google Scholar
  81. 81.
    Jackson JA, Fink GR: Nature 292:306–311, 1981.Google Scholar
  82. 82.
    Biro PA, Pan J, Sood AK, Kole R, Reddy VB, Weissman SM: Cold Spring Harbor Symp Quant Biol 47:1082–1086, 1982.Google Scholar
  83. 83.
    Borst P, Cross GA: Cell 29:291–303, 1982.Google Scholar
  84. 84.
    Ollo R, Rougeoun F: Cell 32:515–523, 1983.Google Scholar
  85. 85.
    Weiss E, Golden L, Zakut R, Mellor A, Fahrner K, Kvist S, Flavell RA: EMBO J 2:453–462, 1983.Google Scholar
  86. 86.
    Schulze D, Pease L, Geier S, Reyes A, Sarmiento L, Wallace RB, Nathenson S: Proc Natl Acad Sci USA 80:2007–2011, 1983.Google Scholar
  87. 87.
    Evans GA, Margulies DH, Camerini-Otero R, Ozato K, Seidman JG: Proc Natl Acad Sci USA 79:1994–1998, 1982.Google Scholar
  88. 88.
    Bentley DL, Rabbitts TH: Cell 32:181–189, 1983.Google Scholar
  89. 89.
    Clarke SH, Claflin JL, Rudikoff S: Proc Natl Acad Sci USA 79:3280–3284, 1982.Google Scholar
  90. 90.
    Weiss EH, Mellor A, Golden L, Fahrner K, Simpson E, Hurst J, Flavell RA: Nature 301:671–674, 1983.Google Scholar
  91. 91.
    Wagner Jr R, Meselson M: PNAS 73:4135–4139, 1976.Google Scholar
  92. 92.
    Lu AL, Clark S, Modrich P: PNAS 80:4639–4645, 1983.Google Scholar
  93. 93.
    Dover G: Nature 299:111–117, 1982.Google Scholar
  94. 94.
    Kabat EA: J Immunol 125:961–969, 1980.Google Scholar
  95. 95.
    Wu TT, Kabat EA: Proc Natl Acad Sci USA 79: 5031–5032, 1982.Google Scholar
  96. 96.
    Baltimore D: Cell 24:592–594, 1981.Google Scholar
  97. 97.
    Krawinkel U, Zoebelein G, Bruggemann M, Radbruch A, Rajewsky K: Proc Natl Acad Sci USA 80:4997–5001, 1980.Google Scholar
  98. 98.
    Wu T, Kabat E, Bilofsky H: Proc Natl Acad Sci USA 76:4617–4621, 1979.Google Scholar
  99. 99.
    Kabat EA, Wu T, Bilofsky H: J Exp Med 149:1299–1313, 1979.Google Scholar
  100. 100.
    Ben-Sasson S: Proc Natl Acad Sci USA 76:4598–4602, 1979.Google Scholar
  101. 101.
    Wuilmart C, Urbain C, Givol D: Proc Natl Acad Sci USA 74:2526–2530, 1977.Google Scholar
  102. 102.
    Leder P, Honjo T, Seidman J Swan D: Cold Spring Harbor Symp Quant Biol 41:855–862, 1976.Google Scholar
  103. 103.
    Loh D, Baltimore D: In preparation.Google Scholar
  104. 104.
    Kreitman M: Nature 304:412–417, 1983.Google Scholar
  105. 105.
    Robinson RR, Germain RN, McKean DJ, Mescher M, Seidman JG: J Immunol 131:2025–2031, 1983.Google Scholar
  106. 106.
    Benoist CO, Mathis DJ, Kanter MR, Williams II VE, McDevitt HO: Cell 34:169–177, 1983.Google Scholar
  107. 107.
    McClintock B: CSH 21:197–216, 1956.Google Scholar
  108. 108.
    Calabretta B, Robberson DL, Barrera-Saldana HA, Lamambrou TP, Saunders GF: Nature 296:219–225, 1982.Google Scholar
  109. 109.
    Ottolenghi S, Giglioni B: Nature 300:770–771, 1982.Google Scholar
  110. 110.
    O'Hare K, Rubin GM: Cell 34:25–35, 1983.Google Scholar
  111. 111.
    Davis M, Kim S, Hood L: Science 209:1360–1365, 1980.Google Scholar
  112. 112.
    Gearhart P, Bogenhagen D: Proc Natl Acad Sci USA 80:3439–3443, 1983.Google Scholar
  113. 113.
    Pech M, Hochtl J, Schnell H, Zachau H: Nature 291:668–670, 1981.Google Scholar
  114. 114.
    Cox EC, Yanofsky C: Proc Natl Acad Sci USA 58:1895–1902, 1967.Google Scholar
  115. 115.
    Loeb L, Kunkel T: Ann Rev Biochem 52:429–457, 1982.Google Scholar
  116. 116.
    Baltimore D, Silverstone A, Kung P, Harrison T, McCaffrey R: Cold Spring Harbor Symp Quant Biol 41:63–72, 1976.Google Scholar
  117. 117.
    Smithies O, Engels WR, Devereux JR, Slightom JL, Shen S: Cell 26:345–353, 1981.Google Scholar
  118. 118.
    Langley V, Montgomery E, Quattlebaum W: Proc Natl Acad Sci USA 79:5631–5635, 1982.Google Scholar
  119. 119.
    Chirikjian J: Gene Amplification and Analysis, Vol 1. Elsevier, New York, 1981.Google Scholar
  120. 120.
    Landy A, Ross W: Science 197:1147–1160, 1977.Google Scholar
  121. 121.
    Temin H: Cell 28:5–6, 1982.Google Scholar

Copyright information

© Martinus Nijhoff Publishers 1984

Authors and Affiliations

  • Lynn Helena Caporale
    • 1
  1. 1.Department of BiochemistryGeorgetown University Medical CenterWashingtonUSA

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