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Therapeutic effects of 6-azauridine-triacetate in psoriasis

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Summary

In a controlled clinical trial 6-azauridinetriacetate, a drug that inhibits the synthesis of pyrimidine “de novo”, had a therapeutic effect in psoriasis. The general tolerance of the drug is good. However, with the dosage of 150 mg/kg/day the leucocytes and erythrocytes of the peripheral blood may drop after 5–6 weeks, the effect depending on the dosage. 270 mg/kg/day may be administered for several weeks. 400 mg/kg/day have early therapeutic effects but cannot be administered for longer periods because of the side-effects mentioned. Only serious cases of psoriasis should be treated with this drug, as with cytostatics in general.

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Authors and Affiliations

  1. Institute of Pharmacology, Czechoslovak Academy of Sciences, Department of Pharmacology, Faculty of Pediatrics, Charles University, Prague, and Division of Dermatology, Regional Hospital, Usti n., Labem

    M. Slavík, J. Elis, H. Rašková, M. Gutová, M. Duchková, M. Kubíková & V. Seyček

Authors
  1. M. Slavík
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  2. J. Elis
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  3. H. Rašková
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  4. M. Gutová
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  5. M. Duchková
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  6. M. Kubíková
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  7. V. Seyček
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Slavík, M., Elis, J., Rašková, H. et al. Therapeutic effects of 6-azauridine-triacetate in psoriasis. Pharmacol. Clin. 2, 120–125 (1970). https://doi.org/10.1007/BF00420718

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  • DOI: https://doi.org/10.1007/BF00420718

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