Advertisement

Inotrope Effekte von ATP und Adrenalin am hypodynamen Froschmyokard nach elektro-mechanischer Entkoppelung durch Ca++-Entzug

  • H. Antoni
  • G. Engstfeld
  • A. Fleckenstein
  • E. Schöpf
Article

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Bay, E. B., C. F. McLean and A. B. Hastings: Electrical and mechanical changes in isolated heart following changes in calcium content of perfusing fluid. Proc. Soc. exp. Biol. (N.Y.) 30, 1346–1347 (1933).Google Scholar
  2. Bogue, J. Y., and R. Mendez: The mechanical and electrical response of the frog's heart. J. Physiol. (Lond.) 67, 31 (1929).Google Scholar
  3. Brooks, C. M., B. F. Hoffman, E. E. Suckling and O. Orias: Excitability of the heart. New York: Grune and Stratton 1955.Google Scholar
  4. Bülbring, E., and H. Lüllmann: The effect of metabolic inhibitors on the electrical and mechanical activity of the smooth muscle of the guinea pig's taenia coli. J. Physiol. (Lond.) 136, 310–323 (1957).Google Scholar
  5. Daly, I. De B., and A. J. Clark: The action of ions upon the frog's heart. J. Physiol. (Lond.) 54, 367–383 (1921).Google Scholar
  6. Dudel, J., u. W. Trautwein: Elektrophysiologische Messungen zur Strophanthinwirkung am Herzmuskel. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 232, 393–407 (1958).Google Scholar
  7. Ellis, S.: The influence of enzyme inhibitors on the action of epinephrine on the frog's heart. J. Pharmacol. exp. Ther. 105, 381–390 (1952).Google Scholar
  8. Ellis, S.: The importance of metabolic pathways for the positive inotropic actions of cardiac glycosides and calcium-ions. J. Pharmacol. exp. Ther. 109, 233–243 (1953).Google Scholar
  9. Fleckenstein, A., H. Hochrein u. H. Kotowski: Aufhebung der Kalium-Lähmung des isolierten Froschherzens durch Adenosintriphosphat. Pflügers Arch. ges. Physiol. 265, 485–487 (1958).Google Scholar
  10. Hoffman, B. F., and E. E. Suckling: Microelectrode studies of repolarisation in the dog ventricle. Abstr. 19th internat. physiol. Congr. 470–471 (1953).Google Scholar
  11. Hoffman, B. F., and E. E. Suckling: Effects of several cations on transmembrane potentials of cardiac muscle. Amer. J. Physiol. 186, 317–324 (1956).Google Scholar
  12. Konschegg, A. V.: Über Beziehungen zwischen Herzmittel- und physiologischer Kationenwirkung. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 71, 251–260 (1913).Google Scholar
  13. Kotowski, H., H. Antoni u. A. Fleckenstein: Elektrophysiologische Studien zur Aufhebung der Kaliumlähmung des Froschmyocards durch ATP. Pflügers Arch. ges. Physiol. 270, 85–102 (1959).Google Scholar
  14. Kukovetz, W. R., N. Hangaard, M. E. Hess u. J. Shanfeld: Zur Frage der Beziehung zwischen Kontraktion und Phosphorylaseaktivität des Rattenherzens. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 238, 119–121 (1960).Google Scholar
  15. Kukovetz, W. R., M. E. Hess, J. Shanfeld and N. Hangaard: The action of sympathomimetic amines on isometric contraction and phosphorylase activity of the isolated rat heart. J. Pharmacol. exp. Ther. 127, 122–127 (1959).Google Scholar
  16. Kuschinsky, G., H. Lüllmann u. E. Muscholl: Die Trennung von Erregungsvorgang und Kontraktion am Skelet- und Herzmuskel durch 2.4.-Dinitrophenol. Naturwissenschaften 45, 520 (1958).Google Scholar
  17. Lepeschkin, E., B. Suravicz, H. Herrlich and B. F. Hoffman: Effect of potassium and calcium deficiency on monophasic action potential of isolated perfused rabbit heart. Fed. Proc. 16, 79 (1957).Google Scholar
  18. Loewi, O.: Über den Zusammenhang zwischen Digitalis- und Calciumwirkung. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 82, 131–158 (1917).Google Scholar
  19. Lundin, G., and G. Ström: The influence of g-strophantin on hypodynamic and anoxic heart muscle of the frog. Acta physiol. scand. 15, 279–285 (1948).Google Scholar
  20. Mandelstamm, M.: Über den Zusammenhang zwischen Digitalis- und Calciumwirkung. Z. ges. exp. Med. 51, 633–658 (1926).Google Scholar
  21. Marshall, J. M., and E. C. Andrus: Comparison of effects of various phosphate compounds and aluminium silicate on isolated frog heart. Proc. Soc. exp. Biol. Med. (N.Y.) 82, 228–231 (1953).Google Scholar
  22. Mines, G. R.: On functional analysis by the action of electrolytes. J. Physiol. (Lond.) 46, 188–235 (1913).Google Scholar
  23. Niedergerke, R.: The staircase phenomenon and the action of calcium on the heart. J. Physiol. (Lond.) 134, 569–583 (1956).Google Scholar
  24. Niedergerke, R.: The potassium chloride contracture of the heart and its modification by calcium. J. Physiol. (Lond.) 134, 584–599 (1956).Google Scholar
  25. Rodeck, H.: Über die Wirkung des Calciums auf den Aktionsstrom des Kaltblüterherzens. Pflügers Arch. ges. Physiol. 249, 470–479 (1947).Google Scholar
  26. Suravicz, B., E. Lepeschkin, H. C. Herrlich and B. F. Hoffman: Effect of potassium and calcium deficiency on the monophasic action potential, electrocardiogram and contractility of isolated rabbit hearts. Amer. J. Physiol. 196, 1302–1307 (1959).Google Scholar
  27. Weidmann, S.: Effects of calcium ions and local anaesthetics on electrical properties of purkinje fibers. J. Physiol. (Lond.) 129, 568–582 (1955).Google Scholar
  28. Weizsäcker, V. v.: Einige Beobachtungen über die Verteilung sowie die arbeitssteigernde Wirkung von Herzglykosiden. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 81, 247–260 (1917).Google Scholar
  29. Woodbury, J. W., and A. J. Brady: Intracellular recording from moving tissues with a flexible mounted ultramicroelectrode. Science 123, 100–101 (1956).Google Scholar
  30. Woodbury, L. A., and H. H. Hecht: Effects of cardiac glycosides upon the electrical activity of single ventricular fibers of the frog heart, and their relation to the digitalis effect of the electrocardiogram. Circulation 6, 172–182 (1952).Google Scholar

Copyright information

© Springer-Verlag 1960

Authors and Affiliations

  • H. Antoni
    • 1
  • G. Engstfeld
    • 1
  • A. Fleckenstein
    • 1
  • E. Schöpf
    • 1
  1. 1.Aus dem Physiologischen Institut der Universität Freiburg i. Br.Germany

Personalised recommendations