Skip to main content
Log in

The glucose- and ethanol-dependent regulation of PDC1 from Saccharomyces cerevisiae are controlled by two distinct promoter regions

  • Published:
Current Genetics Aims and scope Submit manuscript

Summary

A 870 by promoter fragment of the PDC1 gene that includes the carbon source dependent regulatory regions was investigated using 5′ and 3′ promoter deletions. The results indicate that glucose and ethanol regulation of PDC1 transcription are independently controlled by distinct cis-acting regions. The consensus sequence AAATCGATA may play a role in this regulation, while the sequence (ATCA)AACCT may be important in transcription initiation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Beggs JD (1978) Nature 275:104–109

    Google Scholar 

  • Bram RJ, Kornberg RD (1985) Proc Natl Acad Sci USA 82:43–47

    Google Scholar 

  • Breunig KD, Mackedonski V, Hollenberg CP (1982) Gene 20:110

    Google Scholar 

  • Brindle PK, Holland JP, Cohen RG, Holland MJ (1986) Yeast 2:38

    Google Scholar 

  • Clifton D, Fraenkel DG (1981) J Biol Chem 256:13074–13078

    Google Scholar 

  • Cohen R, Holland JP, Yokoi T, Holland MJ (1986) Mol Cell Biol 6:2287–2297

    Google Scholar 

  • Dobson MJ, Futcher AB, Cox BS (1980) Curr Genet 2:193–200

    Google Scholar 

  • Erhart E, Hollenberg CP (1983) J Bacteriol 156:625–635

    Google Scholar 

  • Giniger E, Varnum SM, Ptashne M (1985) Cell 40:767–774

    Google Scholar 

  • Guarente L, Mason T (1983) Cell 32:1279–1286

    Google Scholar 

  • Guarente L, Ptashne M (1981) Proc Natl Acad Sci USA 78:2199–2203

    Google Scholar 

  • Holland MJ, Holland JP (1978) Biochemistry 17:4900–4907

    Google Scholar 

  • Hollenberg CP (1982) Curr Top Immunol 96:119–144

    Google Scholar 

  • Hollenberg CP, Roggenkamp R, Breunig KD, Reipen G (1983) In: Korhola M, Savonen T (eds) Gene expression in yeast. Proceedings of the Alko Yeast Symposium, Helsinki, pp 73–90

  • Hope IA, Struhl K (1985) Cell 43:177–188

    Google Scholar 

  • Johnston M, Davis RW (1984) Mol Cell Biol 4:1440–1448

    Google Scholar 

  • Kadonaga JT, Gautier AE, Straus DR, Charles AD, Edge MD, Knowles JR (1984) J Biol Chem 259:2149–2154

    Google Scholar 

  • Kellermann E, Seeboth PG, Hollenberg CP (1986) Nucleic Acids Res 14:8963–8977

    Google Scholar 

  • Klebe RJ, Harris JV, Sharp ZD, Douglas MG (1983) Gene 25:333–341

    Google Scholar 

  • Maniatis T, Fritsch EF, Sambrook J (1982) Molecular cloning. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY

    Google Scholar 

  • Messing J, Viera J (1982) Gene 19:269–276

    Google Scholar 

  • Ogden JE, Stanway C, Kim S, Mellor J, Kingsman SM, Kingsman AJ (1986) Mol Cell Biol 6:4335–4343

    Google Scholar 

  • Pfeifer K, Prezant T, Guarente L (1987) Cell 49:19–27

    Google Scholar 

  • Reipen G, Erhart E, Breunig KD, Hollenberg CP (1982) Curr Genet 6:189–193

    Google Scholar 

  • Roggenkamp RO, Kustermann-Kuhn B, Hollenberg CP (1981) Proc Natl Acad Sci USA 78:4466–4470

    Google Scholar 

  • Roggenkamp RO, Dargatz H, Hollenberg H (1985) J Biol Chem 260:1508–1512

    Google Scholar 

  • Sanger F, Nicklen S, Coulson AR (1977) Proc Natl Acad Sci USA 65:499–560

    Google Scholar 

  • Sarokin L, Carlson M (1984) Mol Cell Biol 4:2750–2757

    Google Scholar 

  • Schmitt HD, Zimmermann FK (1982) J Bacteriol 151:1146–1152

    Google Scholar 

  • Schmitt HD, Ciriacy M, Zimmermann FK (1983) Mol Gen Genet 192:247–252

    Google Scholar 

  • Stinchcomb DT, Thomas M, Kelley J, Selker E, Davis RW (1980) Proc Natl Acad Sci USA 77:4559–4563

    Google Scholar 

  • Struhl K (1982) Nature 300:284–287

    Google Scholar 

  • Struhl K (1987) Cell 49:295–297

    Google Scholar 

  • Towbin H, Stachelin T, Gordon J (1979) Proc Natl Acad Sci USA 76:4350–4354

    Google Scholar 

  • Uemura H, Shiba T, Paterson M, Jigami Y, Tanaka H (1986) Gene 45:67–75

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kellermann, E., Hollenberg, C.P. The glucose- and ethanol-dependent regulation of PDC1 from Saccharomyces cerevisiae are controlled by two distinct promoter regions. Curr Genet 14, 337–344 (1988). https://doi.org/10.1007/BF00419991

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00419991

Key words

Navigation