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Penetration of atenolol in the rabbit eye

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Summary

The ocular penetration of topically applied [14C]-atenolol in the rabbit was determined by means of liquid scintillation counting. Only one eye was treated, the fellow eye serving as a control. Blood plasma levels were measured as well.

The absolute amount of atenolol which penetrated the eye was very low, but a relatively high concentration was achieved in the tissues of the nictitating membrane. We could only detect an increase in the amount of atenolol with time in the aqueous humor. In all other ocular tissues, including iris and ciliary body, the atenolol level remained constant with time. Hardly any atenolol could be detected in the untreated eye and none in the blood plasma.

These findings suggest that the ocular penetration of atenolol administered as an eye drop is very poor. Ocular penetration, therefore, hardly seems to play a part in the antiglaucomatous effect of atenolol.

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References

  • Barrett, A.M.: The pharmacology of atenolol. Postgrad. Med. J. 53, 58–64 (1977)

    Google Scholar 

  • Brenkman, R.F.: Ocular hypotensive effect of atenolol 4% eye drops in glaucoma. In: Symposium on Medical Therapy in Glaucoma (ed. Greve, E.L.) Docum. Ophthal. Proceedings Series, Vol. 12, 85–94. The Hague: Junk 1977

    Google Scholar 

  • Brogden, R.N., Heel, R.C., Speight, T.M., Avery, G.S.: Metoprolo: a review of its pharmacological properties and therapeutic efficiency in hypertension and angina pectoris. Drugs. 14, 321–348 (1977)

    Google Scholar 

  • Brown, H.C., Carruthers, S.G., Johnston, G.D., Kelly, J.G., McAinsh, J., McDevitt, D.G., Shanks, R.G.: Clinical pharmacologic observations on atenolol, a beta-adrenoceptor blocker. Clin. Pharmacol. Ther. 20, 524–536 (1976)

    Google Scholar 

  • Elliot, M.J., Cullen, P.M.Phillips, C.I.: Ocular hypotensive effect of atenolol (Tenormin®, I.C.I.) A new beta-adrenergic blocker. Br. J. Ophthalmol. 59, 296–300 (1975)

    Google Scholar 

  • MacDonald, M.J., Cullen, P.M., Phillips, C.I.: Atenolol versus propanolol. Br. J. Ophthalmol. 60, 789–791 (1976)

    Google Scholar 

  • MacDonald, M.J., Gore, S.M., Cullen, P.M., Phillips, C.I.: Comparison of the ocular hypotensive effects of acetazolamide and atenolol. Br. J. Ophthalmol. 61, 345–348 (1977)

    Google Scholar 

  • Phillips, C.I., Gore, S.M., MacDonald, M.J., Cullen, P.M.: Atenolol eye drops in glaucoma. A double masked, controlled study. Br. J. Ophthalmol. 61, 349–353 (1977)

    Google Scholar 

  • Ros, F.E., Dake, C.L., Offerhaus, L., Greve, E.L.: Atenolol 4% eye drops and glaucoma. Albrecht v. Graefes Arch. klin. exp. Ophthal. 205, 61–70 (1977)

    Google Scholar 

  • Ros, F.E., Dake, C.L., Nagelkerke, N.D., Greve, E.L.: Metoprolol eye drops in the treatment of glaucoma. Albrecht v. Graefes Arch. klin. exp. Ophthal. 206, 247–254 (1978)

    Google Scholar 

  • Wettrell, K., Pandolfi, M.: Effect of topical atenolol on intraocular pressure. Br. J. Ophthalmol. 61, 334–338 (1977)

    Google Scholar 

  • Zimmerman, Th.J., Kaufman, H.E.: Timolol. A beta adrenergic blocking drug for the treatment of glaucoma. Arch. Ophthalmol. 95, 601–604 (1977a)

    Google Scholar 

  • Zimmerman, Th.J., Kaufman, H.E.: Timolol. Dose response and duration of action. Arch. Ophthalmol. 95, 605–607 (1977b)

    Google Scholar 

Download references

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Authors and Affiliations

  1. Glaucoma Service, Eye Clinic, University of Amsterdam, The Netherlands

    F. E. Ros M.D.

  2. Division of Pharmacotherapy, Department of Pharmacy, University of Amsterdam, Amsterdam, The Netherlands

    H. C. Innemee & P. A. van Zwieten

Authors
  1. F. E. Ros M.D.
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  2. H. C. Innemee
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  3. P. A. van Zwieten
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Ros, F.E., Innemee, H.C. & van Zwieten, P.A. Penetration of atenolol in the rabbit eye. Albrecht von Graefes Arch. Klin. Ophthalmol. 208, 235–240 (1978). https://doi.org/10.1007/BF00419378

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