Summary
An endodermal sinus tumor (endodermal germ cell carcinoma) was diagnosed in a 1-year-old girl in the vagina after vaginal hemorrhage; the tumor was completely removed by radical abdominal surgery. Postoperative polychemotherapy was performed for two years with Actinomycin D, Adriamycin, Vincristin, and Cyclophosphamide. The infant is now tumor-free for 26 months, showing almost normal somatic and psychic development.
The characteristic histological patterns and clinical course of this strongly malignant tumor are demonstrated, based on 25 published casereports of endodermal sinus tumors in the vagina of little girls (aged 5–26 months). This neoplasm in early infancy has to be separated from the clear-cell adenocarcinoma of the vagina which occurs after puberty in adolescent girls and young women, and is induced by stilbestrol therapy to the mother during early pregnancy.
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References
Allyn, D.L., Silverberg, S.G., Salzberg, A.M.: Endodermal sinus tumor of the vagina. Report of a case with 7-year survival and literature review of so-called “mesonephromas”. Cancer 27, 1231–1238 (1971)
Aschheim, R.: Carcinom der Scheide bei einem 8 Monate alten Säugling. 1. Demonstration d. Ges. f. Geburtsh. und Gynäk. zu Berlin am 12.2. 1909. Z. Geburtsh. Gynäk. 65, 216–232 (1910)
Blaustein, A.: Pathology of the female genital tract. Berlin, Heidelberg, New York: Springer 1977
Chak, S.P., Ts'o, T.O.T., Kan, P.S.: A papillary adenocarcinoma of the vagina in an infant. J. Obstet. Gynecol. Br. Emp. 69, 652–654 (1962)
Chao, Y.T., Shan, K.F.: Mesonephric adenocarcinoma of the vagina in an infant. Report of a case. Chin. Med. J. 85, 264–265 (1966)
Dallenbach-Hellweg, G.: Die Cysten und Tumoren der Vagina. In: Handbuch der speziellen pathologischen Anatomie und Histologie, Vol. VII/4, pp. 516–568, Berlin, Heidelberg, New York: Springer 1972
Smet, A.A. de, Silver, T.M., Hart, W.R.: Endodermal sinus tumor of the anterior mediastinum. South Med. J. 70, 757 (1977)
Goto, T., Hattori, T., Uesugi, S., Uesugy, Y.: Case of malignant mesonephroma in 8 month old female infant. J. Jpn. Obstet. Gynecol. Soc. 17, 621–624 (1965)
Herbst, A.L., Scully, R.E.: Adenocarcinoma of the vagina in adolescence. Cancer 25, 745–757 (1970)
Herbst, A.L., Ulfelder, H., Poskanzer, D.C.: Adenocarcinom of the vagina. Association of maternal stilbestrol therapy with tumor appearance in young women. Ny. Engl. J. Med. 284, 878–881 (1971)
Herold, K.: Ein Fall von Scheidencarcinom bei einem 5 Monate alten Kind. Zbl. Gynäk. 57, 1610 (1933)
Huntington, R.W., Jr., Morgenstern, N.L., Sargent, J.A., Giem, R.N., Richards, A., Hanford, K.C.: Germinal tumors exhibiting the endodermal sinus pattern of Teilum in young children. Cancer 16, 34–47 (1963)
Lövegren, E.: Carcinoma vaginae im zweiten Lebensjahr. Acta Paediatr. (Uppsala) 10, 371–378 (1931)
Meyer, R.: Über Adenom- und Carcinombildung an der Ampulle des Gartnerschen Ganges. Virchows Arch. [Pathol. Anat] 174, 270–294 (1903)
Mostofi, F.K.: Epidemiology and pathology of tumors of human testis. In: Grundmann, E., Vahlensieck, W. (eds.). Tumors of the male genital system. Recent results in cancer research, Vol. 60, pp. 176–195. Berlin, Heidelberg, New York: Springer 1977
Norris, H.J., Bagley, G.P., Taylor, H.B.: Carcinoma of the infant vagina. Arch. Pathol. 90, 473–479 (1970)
Novak, E., Woodruff, J.D., Novak, E.R.: Probable mesonephric origin of certain female genital tumors. Am. J. Obstet. Gynecol. 68, 1222–1242 (1954)
Ortmann, K.K.: Über Carcinome der weiblichen Genitalien bei Kindern. Z. Krebsforsch. 37, 283–292 (1932)
Paulussen, F., Maintz, E.J., Gropp, A., Hensen, S.D.: Das mesonephrogene Carcinom im Kindesalter. Geburtsh. Frauenheilk. 31, 228–240 (1971)
Pierce, G.B., Bullock, W.K., Huntington, R.W., Jr.: Yolk sac tumors of the testis. Cancer 25, 644–658 (1970)
Rabl, R.: Carcinom des Gartnerschen Ganges bei einem Säugling. Ein Beitrag zur Entwicklung der paravaginalen malignen Blastome. Virchows Arch. [Pathol. Anat.] 320, 459–475 (1951)
Robboy, S.J., Scully, R.E., Herbst, A.L.: Vaginal and cervical abnormalities related to prenatal exposure to Diethylstilbestrol (DES). In: Blaustein, A. (ed.): Pathology of the female genital tract, pp. 87–101. Berlin, Heidelberg, New York: Springer 1977
Rosen, G.: Management of malignant tumors in children and adolescents. Pediat. Clin. North Am. 23, 183 (1976)
Schiller, W.: Mesonephroma ovarii. Am. J. Cancer 35, 1–21 (1939)
Schöneich, R.: Vaginalcarcinom bei einem 2jährigen Kinde-bisher 12-Jahresheilung. Radiobiol. Radiother. 6, 97–103 (1965)
Shaaban, M.M.: Primary adenocarcinoma of the vagina of mesonephric pattern. Report of a case and review of literature. Aust. NZ. J. Obstet. Gynecol. 10, 55–58 (1970)
Siegel, H.A., Sagerman, R., Berdon, W.E., Wigger, H.J.: Mesonephric adenocarcinoma of the vagina in a 7-month-old infant simulating sarcoma botryoides. Successful control with supervoltage radiotherapy. J. Pediatr. Surg. 5, 468–470 (1970)
Stoeckel, W.: Demonstration eines 10 1/2 Monate alten Kindes, bei dem ein Carcinoma adenomatosum papillosum der vorderen Scheidenwand und der Portio mit Radium behandelt worden ist. Zbl. Gynäk. 63, 801 (1939)
Teilum, G.: Endodermal sinus tumors of the ovary and testis. Cancer 12, 1092–1105 (1959)
Teilum, G.: Classification of endodermal sinus tumor (mesoblastoma vitellinum) and so-called “embryonal carcinoma” of the ovary. Acta Pathol. Microbiol. Scand. 64, 407–429 (1965)
Vawter, G.F.: Carcinoma of the vagina in infancy. Cancer 18, 1479–1484 (1965)
Vuletin, J.C., Rosen, Y., Brigati, D.J., Gourin, A.: Endodermal sinus tumor of the mediastinum. Chest 72, 112–114 (1977)
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Beller, F.K., Nienhaus, H., Schmundt-v. Gizycki, B. et al. Endodermal germ cell carcinoma (endodermal sinus tumor) of the vagina in infant girls. J Cancer Res Clin Oncol 94, 295–306 (1979). https://doi.org/10.1007/BF00419289
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DOI: https://doi.org/10.1007/BF00419289