Summary
Cigarette smoke condensate (CSC) in olive oil was injected into outbred Syrian hamsters: in adults i. p. on the 10th–14th days of gestation, total dose 1.5–2.5 mg/g b. 2.; in 12 to 14-days-old animals s. c., total dose 0.5–1.5 mg/animal. Following 15–25 months of observation benign and malignant neoplasms of various location were found in 2/58 (3.4%) females, treated during pregnancy; in 17/51 (33.3%) of their transplacentally exposed offsprings; in 5/53 (9.4%) of neonatally treated hamsters. In the last two groups females were more affected than males. Most frequently occurred tumors of adrenal glands, pancreas, female sex organs, and liver. No tumors appeared in controls, either untreated or injected with olive oil. In addition, hyperplastic lesions, in particular multiple liver cysts and cholangiomatosis were also observed, mainly in animals exposed transplacentally and as neonates.
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Berman, L.D., Hayes, J.A., Sibay, T.M.: Effect of streptozotocin in the Chinise hamster (Cricetulus griseus). J. Natl. Cancer Inst. 51, 1287–1294 (1973)
Dontenwill, W., Chevalier, H.J., Harke, H.P., Lafrenz, U., Reckzeh, G.: Spontantumoren des syrischen Goldhamsters. Z. Krebsforsch. 80, 127–158 (1973)
Flaks, A.: Test for carcinogenesis of cigarette tobacco smoke condensate using young strong A and C57 Bl mice. Br. J. Cancer 20, 145–147 (1966)
Grice, H.C., Moodie, C.A., Smith, D.C.: The carcinogenic potential of aflatoxin or its metabolites in rats from dams fed aflatoxin pre- and post-partum. Cancer Res. 33, 262–268 (1973)
Hoffmann, D., Ruthkamp, G., Liu, Y.Y.: Chemical studies on tobacco smoke. XXVI. On the isolation and identification of volatile and non-volatile N-nitrosamines and hydrazines in cigarette smoke. In: Bogovski, P., Walker, E.A., (eds.). N-Nitroso compounds in the environment, pp. 159–165 Lyon: IARC 1974
Homburger, F.: The Syrian golden hamster in chemical carcinogenesis research. Progr. Exp. Tumor Res. 10, 163–237 (1968)
Ito, M., Masuko, K., Matsuyama, M., Suzuki, H., Yagayo, T., Aoki, K.: Proliferation of bile ductular cells in the spontaneously hypertensive rat fed N,N′-2,7-fluorenylenbisacetamide. J. Natl. Cancer Inst. 50, 699–706 (1973)
Kirkman, H., Algard, F.T.: Spontaneous and nonviral-induced neoplasms. In: Hoffman, R.A., Robinson, P.F., Magalhaes, H. (Eds.): The golden hamster. its biology and use in medical research, pp. 227–240. Ames: The Yowa State University Press 1968
Lasnitzki, I.: The effect of a hydrocarbon-enriched fraction of cigarette smoke condensate on human fetal lung grown in vitro. Cancer Res. 28, 510–516 (1968)
Leuchtenberger, C., Leuchtenberger, R.: Cytologic and cytochemical effects on primary mouse kidney tissue and lung organ cultures after exposure to whole, fresh smoke and its gas phase from unifiltered, charcoal-filtered, and cigar-tobacco cigarettes. Cancer Res. 29, 862–872 (1969)
Neutel, C.J., Buck, C.: Effect of smoking during pregnancy on the risk of cancer in children. J. Natl. Cancer Inst. 47, 59–63 (1971)
Nicolov, I., Chernozemski, I.: Tumours in Syrian hamsters following transplacental application of cigarette smoke condensate. XI Int. Cancer Congress Abstracts, p. 43, Florence, Vol. 2, 1974
Pathology of the Syrian Hamster. Progr. Exp. Tumor Res. 16, 1–637 (1972)
Pour, P., Kmoch, N., Grieser, E., Mohr, U., Althoff, J., Cardesa, A.: Spontaneous tumors and common diseases in two colonies of Syrian hamsters. I. Incidence and sites. J. Natl. Cancer Inst. 56, 931–935 (1976)
Pour, P., Mohr, U., Cardesa, A., Althoff, J., Kmoch, N.: Spontaneous tumors and common diseases in two colonies of Syrian hamsters. II. Respiratory tract and digestive system. J. Natl. Cancer Inst. 56, 937–948 (1976)
Pour, P., Mohr, U., Althoff, J., Cardesa, A., Kmoch, N.: Spontaneous tumors and common diseases in two colonies of Syrian hamsters. III. Urogenital system and endocrine glands. J. Natl. Cancer Inst. 56, 949–961 (1976)
Pour, P., Mohr, U., Althoff, J., Cardesa, A., Kmoch, N.: Spontaneous tumors and common diseases in two colonies of Syrian hamsters. IV. Vascular and lymphatic system and lesions of other sites. J. Natl. Cancer Inst. 56, 963–974 (1976)
Raichev, R., Chernozemski, I.: On adrenocortical tumors in the Golden hamster. Sci. Papers of the Cancer Research Institute Sofia 11, 11–16 (1967)
Takayama, S.: Carcinogenic effect of cigarette tar using new-born ICR mice. Gann 61, 297–298 (1970)
Tomatis, L., Magee, P.N., Shubik, P., Induction of liver tumors in the Syrian golden hamster by feeding dimethylnitrosamine. J. Natl. Cancer Inst. 33, 341–345 (1964)
Vesselinovitch, S.D.: Comparative studies on perinatal carcinogenesis. In: Tomatis, L., Mohr, U. (Eds.). Transplacental carcinogenesis, pp. 14–22, Lyon: IARC 1973
Wynder, E.L., Hoffmann, D.: Tobacco and tobacco smoke. Studies in experimental carcinogenesis. New York: Academic Press 1967
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Nicolov, I.G., Chernozemsky, I.N. Tumors and hyperplastic lesions in Syrian hamsters following transplacental and neonatal treatment with cigarette smoke condensate. J Cancer Res Clin Oncol 94, 249–256 (1979). https://doi.org/10.1007/BF00419284
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DOI: https://doi.org/10.1007/BF00419284