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Verteilung 35S-markierter sulfatierter Mukopolysaccharide im Empfängerauge nach homologer Keratoplastik

Experimentelle Untersuchungen am Kaninchenauge

Distribution of 35S labeled sulfated mucopolysaccharids in the recipient eye after corneal allografting

Experimental studies in rabbits

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Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie Aims and scope Submit manuscript

Summary

The release of 35S labeled corneal glycoprotein from an allogenic interlamellar corneal graft was studied in randomly selected rabbits. Simultaneously, the uptake of 35S by the recipient animal was investigated. These changes followed for a period of 80 h indicate that there is a constant 35S release from the donor cornea and that it is the recipient cornea which takes up the major part of the 35S from the donor. The iris, choroid, and sclera of the recipient also take up a certain percentage of the donor's 35S while the aqueous humor, the optic nerve, and the local lymph nodes take up only minimal amounts.

Zusammenfassung

Abgabe und Verteilung von 35S-markierten kornealen Glykoproteinen aus einem allogenen interlamellären Hornhauttransplantat wurden über 80 h untersucht. Nach den erhobenen Befunden vollzieht sich eine ständige Abgabe aus der Spenderkornea, wobei die Empfängerhornhaut den größten Teil des abgebenen 35S aufnimmt. Iris, Choreoidea und Sklera nehmen einen gewissen Prozentsatz des aus der Spenderkornea abgeführten 35S auf, während das Kammerwasser, der Sehnerv und die regionären Lymphknoten sich daran nur geringgradig beteiligen.

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Authors and Affiliations

  1. Abteilung Ophthalmologie der Christian-Albrechts-Universität Kiel, Bundesrepublik Deutschland

    G. Stremke & W. Böke

  2. Institut für Experimentelle Biologie und Medizin, Borstel, Bundesrepublik Deutschland

    J. Meißner

Authors
  1. G. Stremke
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  2. J. Meißner
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  3. W. Böke
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Stremke, G., Meißner, J. & Böke, W. Verteilung 35S-markierter sulfatierter Mukopolysaccharide im Empfängerauge nach homologer Keratoplastik. Albrecht von Graefes Arch. Klin. Ophthalmol. 209, 279–290 (1979). https://doi.org/10.1007/BF00419063

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