Summary
In rabbits the i.o. pressure regulation is affected by central stimulated drugs. Urethane and reserpine-urethane inhibit and phenelzine (mono-amino-oxydase-inhibitor) assists the i.o. pressure regulation. By propaphenin (chlor-promazine) the i.o. pressure regulation is not affected. Therefore an i.o. pressure regulation can be investigated only in unnarcotisized animals. The 4 applied psycho-drugs affect differently the i.o. pressure. By urethane anaesthesia and reserpinisation the i.o. pressure decreased significantly and the outflow facility increased. By propaphenin (chlorpromazine) and phenelzine the i.o. pressure is not affected.
Zusammenfassung
Die i.o. Druckregulation bei Kaninchen läßt sich durch zentral angreifende Pharmaka beeinflussen. Urethan und Reserpin-Urethan hemmen, Phenelzin (Monoaminoxydase-Hemmer) fördert die i.o. Druckregulation. Nach Gaben von Propaphenin (Chlorpromazin) wird die i.o. Druckregulation nicht sicher beeinflußt. Eine i.o. Druckregulation kann deshalb nur am unnarkotisierten Tier untersucht werden. Die 4 untersuchten Pharmaka beeinflussen den i.o. Druck unterschiedlich. Durch die Urethan-Narkose und nach Gaben von Reserpin wird der i.o. Druck deutlich herabgesetzt und die Abflußleichtigkeit erhöht. Gaben von Propaphenin und Phenelzin beeinflussen den i.o. Druck nicht.
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Marré, E. Die intraoculare Druckregulation. Albrecht von Graefes Arch. Klin. Ophthalmol. 175, 246–258 (1968). https://doi.org/10.1007/BF00418452
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DOI: https://doi.org/10.1007/BF00418452