Summary
Collagen synthesis in cells with trisomy 7 and 9 derived from human spontaneous abortuses was found to be lower (5.06% and 5.53% respectively) than in the control diploid cells (8.80%). The ratio of collagen types (I/III) in trisomic strains did not differ from the control data while the amount of the degraded procollagen in trisomic cells was increased.
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References
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Kukharenko, V.I., Delvig, A.A. & Grinberg, K.N. Disturbances in collagen synthesis in trisomic cells from spontaneously aborted embryos. Hum Genet 68, 269–271 (1984). https://doi.org/10.1007/BF00418401
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DOI: https://doi.org/10.1007/BF00418401