Abstract
In a series of newly isolated AKR leukemias, some tumors expressed large amounts of both H-2K and H-2D molecules, while others had reduced levels of both antigens. The number of H-2 antigens expressed in steady state showed a consistent correlation with the rate of synthesis of the H-2 class I heavy chain and the beta-2 microglobulin (β 2m) light chain, and with the amount of H-2-and β 2m-specific mRNA present in the tumors. Stimulation of leukemic cells with interferon induced an increased transcription of both H-2 and β 2m mRNA. These results suggest that there is a mechanism that regulates, at the transcriptional level, the coordinate expression of H-2K and H-2D heavy chains, and the β 2m light chains encoded by genes on chromosomes 17 and 2, respectively.
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Schmidt, W., Henseling, U., Bevec, D. et al. Control of synthesis and expression of H-2 heavy chain and beta-2 microglobulin in AKR leukemias. Immunogenetics 22, 483–494 (1985). https://doi.org/10.1007/BF00418093
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DOI: https://doi.org/10.1007/BF00418093