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Study of the 11β-hydroxysteroid dehydrogenase in vitro

II. Influence of neonatal thymectomy in mice

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Summary

Some aspects of the corticosterone metabolism of neonatally thymectomized mice of various ages were compared with those of sham-operated littermates.

No difference was found in relative adrenal weight or unconjugated plasma levels. However, 11β-hydroxysteroid dehydrogenase activity in spleen and kidney homogenate was slightly but significantly increased after neonatal thymectomy. The difference is more marked in C3H×C57 Black cross-bred mice, which are more susceptible to wasting disease, than in NMRI mice.

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References

  1. Daughaday, W., O. Lowry, N. Rosebrough, and W. Fields: Determination of cerebrospinal fluid protein with the Folin phenol reagent. J. Lab. clin. Med. 39, 663–665 (1952).

    Google Scholar 

  2. Day, A., and J. Peters: Observations on clearing factor inhibitor elaborated by cortisone in rabbits. Aust. J. exp. Biol. med. Sci. 36, 121–132 (1958).

    Google Scholar 

  3. Deckx, R., and P. De Moor: Study of the 11β-hydroxysteroid dehydrogenase in vitro. I. Biochemical characterization in spleen homogenate. Pflügers Arch. ges. Physiol. 289, 59–68 (1966).

    Google Scholar 

  4. Fachet, J., I. Szabo, and G. Cseh: Effect of thymectomy on lipoprotein lipase activity in the serum and the heart of rats. Experientia (Basel) 20, 708–709 (1964).

    Google Scholar 

  5. Good, R., A. Dalmasso, C. Martinez, O. Archer, J. Pierce, and B. Papermaster: The role of the thymus in development of immunologic capacity in rabbits and mice. J. exp. Med. 116, 773–795 (1962).

    Google Scholar 

  6. Koerner, O., and L. Hellman: Effect of thyroxine administration on the 11β-hydroxysteroid dehydrogenase in rat liver and kidney. Endocrinology 75, 592–601 (1964).

    Google Scholar 

  7. Mc Intire, K. S. Sell, and J. Miller: Pathogenesis of the post-neonatal thymectomy wasting syndrome. Nature (Lond.) 204, 151–155 (1964).

    Google Scholar 

  8. Miller, J.: Role of the thymus in transplantation immunity. Ann. N. Y. Acad. Sci. 99, 340–354 (1962).

    Google Scholar 

  9. —— The thymus and the development of immunologic responsiveness. Science 144, 1544–1551 (1964).

    Google Scholar 

  10. Moor, P. de, and O. Steeno: Comparison of three techniques for the fluorimetric determination of plasma corticosteroids. J. Endocr. 28, 59–64 (1963)

    Google Scholar 

  11. Papermaster, B., R. Condie, J. Finstad, and R. Good: Evolution of the immune response. I. The phylogenetic development of adaptive immunologic responsiveness in vertebrates. J. exp. Med. 119, 105–130 (1964).

    Google Scholar 

  12. Schlesinger, M., and R. Mark: Wasting disease induced in young mice by administration of cortisol acetate. Science 143, 965–966 (1964).

    Google Scholar 

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Authors and Affiliations

  1. Rega Instituut, Laboratorium voor Experimentele Geneeskunde en Kliniek voor Inwendige Geneeskunde, Universiteitsklinieken St Rafaël, Leuven, Belgium

    P. de Moor & R. Deckx

Authors
  1. P. de Moor
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  2. R. Deckx
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Supported in part by grant n° 564 of the “Nationaal Fonds voor Geneeskundig Wetenschappelijk Onderzoek”.

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de Moor, P., Deckx, R. Study of the 11β-hydroxysteroid dehydrogenase in vitro. Pflügers Arch. 289, 69–74 (1966). https://doi.org/10.1007/BF00417645

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  • DOI: https://doi.org/10.1007/BF00417645

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