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Assignment of the rat genes coding for DOPA decarboxylase (DDC) and glutamic acid decarboxylases (GAD1 and GAD2)

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Abstract

By use of rat cDNA probes and a panel of cell hybrids segregating rat chromosomes, the genes encoding three pyridoxal 5′-phosphate (PLP)-dependent decarboxylases—namely, DOPA-decarboxylase (Ddc), glutamic acid decarboxylase 1 and 2 (Gad1 and Gad2)—were assigned to rat Chromosomes (Chrs) 14, 3, and 17, respectively. If one takes into account chromosome localizations in the human and the mouse, the present results (i) show that a synteny group is retained on rat Chr 14, human Chr 7, and mouse Chr 11 (Ddc); (ii) strengthen the homology relation known between rat Chr 3 and human and mouse Chrs 2 (Gad1); (iii) suggest that rat Chr 17 has no extensive homology to any human chromosome; and (iv) suggest the order (Prl, Fdp)-Tpl2-Gad2 on the rat Chr 17.

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Authors and Affiliations

  1. Laboratoire de Biochimie Cellulaire, Collège de France, F-75231, Paris Cedex 05, France

    Cécile Vassort, Gilles Bruneau, François Gros & Jean Thibault

  2. Département de Biologie Moléculaire, Université Libre de Bruxelles, B-1640, Rhode-St-Genèse, Belgium

    Michèle Rivière, Josiane Szpirer & Claude Szpirer

  3. Department of Genetics, University of Gothenburg, S-40033, Götenborg, Sweden

    Göran Levan

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  1. Cécile Vassort
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  2. Michèle Rivière
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  3. Gilles Bruneau
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  4. François Gros
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  5. Jean Thibault
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  6. Göran Levan
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  7. Josiane Szpirer
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  8. Claude Szpirer
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Vassort, C., Rivière, M., Bruneau, G. et al. Assignment of the rat genes coding for DOPA decarboxylase (DDC) and glutamic acid decarboxylases (GAD1 and GAD2). Mammalian Genome 4, 202–206 (1993). https://doi.org/10.1007/BF00417563

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  • DOI: https://doi.org/10.1007/BF00417563

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