Abstract
Twenty-seven patients with ocular hypertension or open angle glaucoma were tested to see if, and to what extent, timolol and dipivalyl-epinephrine produced a supplementary reduction of intraocular pressure. In a shortterm study, 14 patients were tested with timolol (0.1%) and dipivalyl-epinephrine (0.25%). Simultaneous application of both substances produced a statistically more significant reduction of intraocular pressure than either timolol (0.1%) or dipivalyl-epinephrine (0.25%) alone. In 13 patients a comparison was made between patients who received both timolol (0.25%) and dipivalyl-epinephrine (0.1%) bis· and patients who received only timolol (0.25%) bis· over a period of 6, 9 and 12 weeks. Both substances used in combination produced a statistically more significant reduction in intraocular pressure than timolol (0.25%) bis· alone. The simultaneous application of an α- and β-adrenergic agonist and β-adrenergic antagonist is not contradictory. The results are discussed on the basis of the mode of action of the applied substances.
Zusammenfassung
An 27 Patienten mit Hypertensio oculi oder Glaucoma simplex wurde geprüft, ob und in welchem Ausmaß Timolol und Adrenalindipivalat eine ergänzende Wirkung in der Senkung des Augendruckes entfalten. In einer Kurzzeituntersuchung wurde an 14 Patienten der kurzfristige additive drucksenkende Effekt von Timolol 0,1% und Adrenalindipivalat 0,25% geprüft. Dabei zeigte sich, daß beide Substanzen, gemeinsam appliziert, eine signifikant stärkere Senkung des Augendruckes bewirken als Timolol 0,1 % oder Adrenalindipivalat 0,25% alleine. An 13 Patienten wurde die gemeinsame Anwendung von Timolol 0,25% und Adrenalindipivalat 0,1% die mit der ausschließlichen Gabe von Timolol 0,25% die nach sechs, neun und zwölf Wochen verglichen. Beide Substanzen gemeinsam bewirkten in der sechsten, neunten und zwölften Woche eine statistisch signifikant stärkere Senkung des Augeninnendruckes als Timolol alleine. Die gleichzeitige Anwendung von Agonist am α- und β-Rezeptor und Antagonist am β-Rezeptor stellt keinen Widerspruch dar. Die Ergebnisse werden vor dem Hintergrund der Wirkungsweise beider Pharmaka und im Vergleich mit der vorliegenden Literatur diskutiert.
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Ober, M., Scharrer, A. Timolol und Adrenalindipivalat bei der Behandlung des erhöhten intraocularen Druckes. Albrecht von Graefes Arch. Klin. Ophthalmol. 213, 273–281 (1980). https://doi.org/10.1007/BF00417550
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DOI: https://doi.org/10.1007/BF00417550