Summary
Changes in the ratio of active and total E rosettes of 12 untreated and 26 corneal transplant patients with immunosuppressive therapy were examined weekly for a month and in the third month. On the basis of our results it can be stated that keratoplasty increases immune reactivity. This manifests itself in the increasing number of both the active and total E-rosette-forming lymphocytes. This increase in T cell number can be observed also after cataract operations in the first week, but in the latter case if no rejection occurs after keratoplasty the ratio of E-rosette-forming cells returns to the preoperative value in the third week. If the T-lymphocyte number is increased as late as the third week, that can be regarded as a rejection sign. Our data confirm the significance of active E-rosette-forming cells in immunological processes.
Examination of the active and total E-rosette-forming T-lymphocytes has proved a suitable method for following up the cellular immunological processes directed against the corneal transplant.
Zusammenfassung
Veränderungen in der aktiven und totalen E-Rosetten-Ratio von 12 unbehandelten und 26 durch immunosuppressive Therapie behandelten Patienten mit Hornhauttransplantationen wurden einen Monat lang wöchentlich sowie nach 3 Monaten untersucht. Unsere Ergebnisse zeigen, daß die erhöhte Anzahl der aktiven und totale E-Rosetten bildenden Lymphocyten auf der wegen der Keratoplastik erhöhter Immunreaktivität beruht. Diese Vermehrung kann auch die erste Woche nach der Staroperation beobachtet werden. Aber nach der Keratoplastik, wenn keine Abstoßung des Transplantats erfolgt, wird in der dritten Woche die preoperative Ration der E-Rosetten wieder erreicht. Als Abstoßungssymptom kann gelteri, wenn die Anzahl der T-Eymphocyten auch die dritte Woche erhöht ist. Unsere Befunde sprechen für die Signifikanz der aktiven E-Rosettenbildung beim immunologischen Geschehen.
Das Studiuni der aktiven und totalen E-Rosettenbildung hat sich als eine geeignete Methode zur Untersuchung der gegen das Hornhauttransplantat entwickelten zellulären immunologischen Prozesse erwiesen.
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Kelenhegyi, C., Süveges, I. & Alberth, B. Change of T-lymphocyte ratio after keratoplasty. Albrecht von Graefes Arch. Klin. Ophthalmol. 210, 269–274 (1979). https://doi.org/10.1007/BF00417540
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DOI: https://doi.org/10.1007/BF00417540