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Stimulation of T cells by autologous mononuclear leukocytes and epidermal cells in psoriasis

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Summary

Based on reports suggesting aberrant cell-mediated immunity and altered infiltration of immunocompetent cells into the skin in psoriasis, we studied the stimulation of T cells by autologous non-T mononuclear leukocytes (autologous mixed lymphocyte reaction, AMLR) and by epidermal cells isolated from lesional and clinically uninvolved skin in psoriasis (autologous mixed epidermal cell lymphocyte reaction, AMECLR). Age- and sex-matched individuals served as controls. We found that the AMLR in psoriasis (n=11) was similar to that in healthy controls (n=16); furthermore, cell proliferation was alike in the presence of either 5% AB-serum or autologous serum. By contrast, while the AMECLR in healthy controls (n=9) resembled that in psoriatics employing epidermal cells from univolved skin, epidermal cells from lesional sites (n=10) induced a significantly higher proliferation of autologous T cells in the AMECLR (P<0.01). We conclude that the in vitro stimulation of T cells by non-T mononuclear leukocytes is normal in psoriasis and is not regulated by autologous serum. Lesional psoriatic epidermal cells, however, are more active in stimulating autologous T cell proliferation than cells from univolved psoriatic or normal epidermis.

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Authors and Affiliations

  1. Hautklinik, Johannes-Gutenberg-Universität, D-6500, Mainz, Germany

    R. E. Schopf, A. Hoffmann, M. Jung, B. Morsches & K. Bork

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  1. R. E. Schopf
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  2. A. Hoffmann
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  3. M. Jung
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  4. B. Morsches
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  5. K. Bork
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Schopf, R.E., Hoffmann, A., Jung, M. et al. Stimulation of T cells by autologous mononuclear leukocytes and epidermal cells in psoriasis. Arch Dermatol Res 279, 89–94 (1986). https://doi.org/10.1007/BF00417528

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  • DOI: https://doi.org/10.1007/BF00417528

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