Abstract
Over a period of 4 months, 16 of 24 patients (30 of 46 eyes) with either primary open angle glaucoma (POAG) or suspected glaucoma were treated successfully with a maintenance dose of guanethidine (3%) and adrenaline (0.5%) combined in one eyedrop (GA) once daily. In the previous month the medication was given twice daily and at the end of 4 months the decrease in intraocular pressure (IOP) was 8.9 mm Hg (33%) compared to 9.9 mm Hg (37%) with twice-daily application; three of four eyes responded just as well to single-daily application as to twice daily application of GA. Once-daily treatment with GA was not successful when the average IOP in the absence of treatment was over 32 mm Hg. The advantages of once-daily application were less conjunctival hyperemia, less dilation of the pupils, less ptosis and difficulty reading, plus the advantage that the drops needed only to be applied once a day (patient compliance). The recommended regime for GA therapy in patients with an IOP of less than 32 mm Hg is application of GA twice daily for 1 month followed by a decrease in the dosage to once a day. GA can best be applied in the evening before retiring.
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References
Holland MG, Wei CP (1973a) Epinephrine dose-response characteristics of glaucomatous human eyes following chemical sympathectomy with 6-hydroxydopamine. Ann Ophthalmol 5/6:633–640
Holland MG, Wei, CP (1973b) Chemical sympathectomy in glaucoma. Therapy: An investigation of alpha- and beta-adrenergic supersensitivity. Ann Ophthalmol 5/7:783–796
Hoyng PFJ, Dake CL (1979) The combination of guanethidine (3%) and adrenaline (0.5%) in 1 eyedrop (GA) in glaucoma treatment. Br J Ophthalmol 63:56–62
Mitchell JR, Oates, JA (1970) Guanethidine and related agents. Mechanism of the selective blockade of adrenergic neurons and its antagonism by drugs. J Pharmacol Exp Ther 172:100–107
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Hoyng, P.F.J., Dake, C.L. Maintenance therapy of glaucoma patients with guanethidine (3%) and adrenaline (0.5%) once daily. Albrecht von Graefes Arch. Klin. Ophthalmol. 214, 269–275 (1980). https://doi.org/10.1007/BF00417523
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DOI: https://doi.org/10.1007/BF00417523