Skip to main content
SpringerLink
Log in

The aqueous humor dynamics and the biphasic response in intraocular pressure induced by guanethidine and adrenaline in the glaucomatous eye

  • Published:
Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie Aims and scope Submit manuscript

Abstract

Continuous administration of guanethidine (3%) and adrenaline (0.5%) in one eyedrop (GA) induced a biphasic response of intraocular pressure (IOP). In ten patients with primary open angle and seven glaucoma suspects treated with (GA) twice daily during a 7 month period, tonography, and tonometry were performed and the pupil diameter measured 3 and 8 h post-GA. The combined data of both groups in the hypertensive phase, showed an IOP increase of 2.8 mm Hg (P<0.05), an unchanged coefficient of the outflow, dilated pupil (1.73 mm) (P<0.005) and a 36% increase of aqueous humor production (P<0.02). The specific biphasic course of IOP during treatment with GA seems to be caused by fluctuations in aqueous humor production. The increase in aqueous rate during the hypertensive phase could be related to secondary (rebound) vasodilation in the ciliary body and/or to a transient disruption of the blood-aqueous barrier induced by release of prostaglandins.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Alphen GWHM van (1976) The adrenergic receptors of the intraocular muscles of the human eye. Invest Ophthalmol 15:502–505

    Google Scholar 

  • Holland MG, Wei CP (1973) Epinephrine dose-response characteristics of glaucomatous human eyes following chemical sympathectomy with 6-hydroxydopamine. Ann Opthalmol 5/6:633–640

    Google Scholar 

  • Hoyng PhFJ, Dake CL (1979) The combination of guanethidine 3% and adrenaline 0.5% in one eye drop GA in glaucoma treatment. BrJ Ophthalmol 63:56–62

    Google Scholar 

  • Langham ME, Krieglstein GK (1976) The biphasic intraocular pressure response of rabbits to epinephrine. Invest Ophthalmol 15:119–127

    Google Scholar 

  • Langham ME, Palewicz K (1977) The pupillary, the intraocular pressure and the vasomotor response to noradrenaline in rabbits. J Physiol (London) 267:339–355

    Google Scholar 

  • Moses RA, Becker B (1958) Clinical tonography: The sceral rigidity correction. Amer J Ophthal 45:196–208

    Google Scholar 

  • Unger WG, Hammond BR (1977) Noradrenaline-induced inflammation in the sympathectomized rabbit eye. IRCS Med Sci 5:563

    Google Scholar 

  • Waitzman MB, Woods WD (1979) Effects of prostaglandins, norepinephrine on intraocular pressure and pupil size in rabbits following cervical ganglionectomy. Invest Ophthalmol 18:52–60

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology, University of Amsterdam, le Helmersstraat 104, 1054 EG, Amsterdam, The Netherlands

    Ph. F. J. Hoyng & C. L. Dake

Authors
  1. Ph. F. J. Hoyng
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. L. Dake
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hoyng, P.F.J., Dake, C.L. The aqueous humor dynamics and the biphasic response in intraocular pressure induced by guanethidine and adrenaline in the glaucomatous eye. Albrecht von Graefes Arch. Klin. Ophthalmol. 214, 263–268 (1980). https://doi.org/10.1007/BF00417522

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00417522

Keywords

Search

Navigation