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Immunotherapy in corneal herpes

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Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie Aims and scope Submit manuscript

Abstract

Experiments have shown that F(ab)′2-fragments can be demonstrated intracellularly. Herpes simplex antibodies in the form of pepsin-split gamma globulin are effective in cases of dendritic keratitis. An additive effect is seen if local antibody therapy is combined with trifluorothymidine treatment.

Zusammenfassung

In Experimenten konnte bereits gezeigt werden, daß F(ab)′2-Fragmente die Zellwand durchdringen können. Herpes-Antikörper in Form derartiger pepsingespaltener Gammaglobuline zeigen bei lokaler Applikation eine therapeutische Wirkung bei der Behandlung der Keratitis dendritica am Menschen. Wird zusätzlich noch Trifluorthymidin gegeben, führt dies zu einer Steigerung des Effektes gegenüber einer jeweiligen Monotherapie.

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Authors and Affiliations

  1. University Ophthalmology Clinic, Anichstr. 35, A-6020, Innsbruck, Austria

    M. Zirm

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  1. M. Zirm
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Zirm, M. Immunotherapy in corneal herpes. Albrecht von Graefes Arch. Klin. Ophthalmol. 214, 253–261 (1980). https://doi.org/10.1007/BF00417521

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  • DOI: https://doi.org/10.1007/BF00417521

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