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The mouse homolog of the rhombotin (Ttg-1) gene maps on Chromosome 7 distal to the β-globin (Hbb) locus

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References

  • Boehm, T., Baer, R., Lavenir, I., Forster, A., Waters, J.J., Nacheva, E., and Rabbitts, T.H. (1988). The mechanism of chromosomal translocation t(11;14) involving the T-cell receptor Cδ locus on human chromosome 14q11 and a transcribed region of chromosome 11p15. EMBO J. 7, 385–394.

    Google Scholar 

  • Boehm, T., Greenberg, J.M., Buluwela, L., Lavenir, I., Forster, A., and Rabbitts, T.H. (1990a). An unusual structure of a putative T cell oncogene which allow production of similar proteins from distinct mRNAs. EMBO J. 9, 857–868.

    Google Scholar 

  • Boehm, T., Foroni, L., Kennedy, M., and Rabitts, T.H. (1990b). The rhombotin gene belongs to a class of transcriptional regulators with a potential novel protein dimerization motif. Oncogene 5, 1103–1105.

    Google Scholar 

  • Boehm, T., Spillantini, J.-G., Sofroniew, M.V., Surani, M.A., and Rabitts, T.H. (1991a). Developmentally regulated and tissue specific expression of mRNAs encoding the two alternative forms of the LIM domain oncogene rhombotin: evidence for thymus expression. Oncogene 6, 695–703.

    Google Scholar 

  • Boehm, T., Foroni, L., Kaneko, Y., Perutz, M.F., and Rabbitts, T.H. (1991b). The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. Proc. Natl. Acad. Sci. USA 88, 4367–4371.

    Google Scholar 

  • Fisch, P., Boehm, T., Lavenir, I., Larson, T., Arno, J., Forster, A., and Rabbitts, T.H. (1992). T-cell acute lymphoblastic lymphoma induced in transgenic mice by the RBTN1 and RBTN2 LIM-domain genes. Oncogene 7, 2389–2397.

    Google Scholar 

  • Freyd, G., Kim, S.K., and Horvitz, H.R. (1990). Novel cysteinerich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-11. Nature 344, 876–879.

    Google Scholar 

  • Greenberg, J.M., Boehm, T., Sofroniew, M.V., Keynes, R.J., Barton, S.C., Norris, M.L., Surani, M.A., Spillantini, J.-G., and Rabitts, T.H. (1990). Segmental and developmental regulation of a presumptive T-cell oncogene in the central nervous system. Nature 344, 158–160.

    Google Scholar 

  • Karlsson, O., Thor, S., Norberg, T., Ohlsson, H., and Edlund, T. (1990). Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain. Nature 344, 879–882.

    Google Scholar 

  • McGuire, E.A., Hockett, R.D., Pollock, K.M., Bartholdi, M.F., O'Brien, S.J., and Korsmeyer, S.J. (1989). The t(11;14)(p15q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein. Mol. Cell. Biol. 9, 2124–2132.

    Google Scholar 

  • McGuire, E.A., Rintoul, C.E., Sclar, G.M., and Korsmeyer, S.J. (1992). Thymic overexpression of Ttg-1 in transgenic mice results in T-cell acute lymphoblastic leukemia/lymphoma. Mol. Cell. Biol. 12, 4186–4196.

    Google Scholar 

  • Rinchik, E.M., Magnuson, T., Holdener-Kenny, B., Kelsey, G., Bianchi, A., Conti, C.J., Chartier, F., Brown, K.A., Brown, S.D.M., and Peters, J. (1992). Mouse Chromosome 7. Mammalian Genome 3 (Suppl), S104-S120.

    Google Scholar 

  • Rougeon, F. and Mach, B. (1977). Cloning and amplification of α and β mouse globin gene sequences synthesized in vitro. Gene 1, 229–239.

    Google Scholar 

  • Royer-Pokora, B., Loos, U., and Ludwig, W.-D. (1991). TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11). Oncogene 6, 1887–1893.

    Google Scholar 

  • Saunders, A.M. and Seldin, M.F. (1990). A molecular genetic linkage map of mouse Chromosome 7. Genomics 8, 525–535.

    Google Scholar 

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Angel, J.M., Moore, J.L., Pelphrey, A. et al. The mouse homolog of the rhombotin (Ttg-1) gene maps on Chromosome 7 distal to the β-globin (Hbb) locus. Mammalian Genome 4, 281–282 (1993). https://doi.org/10.1007/BF00417437

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  • DOI: https://doi.org/10.1007/BF00417437

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