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Glucocorticoids and intraocular pressure

An experimental study

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Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie Aims and scope Submit manuscript

Summary

The state of intraocular pressure and aqueous humor dynamics as well as histomorphologic and histochemical change of the eye tissues as a result of administration of glucocorticoids were studied in 62 rabbits. After administration of glucocorticoids by instillations and subconjunctival injections there was a trend toward increased intraocular pressure but no statistically significant change in the intraocular pressure was demonstrated. When glucocorticoids were administered for 1 month, a significant increase in production and outflow of aqueous humor was established. Continuation of the experiments for 2 months or longer was accompanied by a significant decrease of the outflow facility coefficient and inhibition of aqueous humor formation. Histologic and histochemical examinations of the eyes of the rabbits studied for 2 months revealed marked dystrophic changes in the trabecular meshwork tissues.

Zusammenfassung

Bei 62 Kaninchen wurden der intraoculare Druck und die Kammerwasserdynamik sowie histomorphologische und histochemische Veränderungen des Augengewebes nach der Verabreichung von Corticosteroiden untersucht. Nach Glucocorticoidgaben in Form von Augentropfen und subconjunctivalen Injektionen zeigte sich eine Tendenz zu erhöhtem Augeninnnendruck, der jedoch nicht statistisch signifikant war. Wurden dagegen Glucocorticoide einen Monat lang gegeben, so kam es zu einem signifikanten Anstieg der Kammerwasserproduktion und des Kammerwasserabflusses. Eine Fortsetzung der Versuche über 2 Monate und länger führte zu einem signifikanten Abfall der Abflußleichtigkeit und zu einer Hemmung der Kammerwasserbildung. Histologische und histochemische Untersuchungen der Augen der Kaninchen 2 Monate nach dem Versuchsbeginn ergaben deutliche dystrophische Veränderungen im Trabekelwerk.

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Authors and Affiliations

  1. Helmholtz Research Institute of Eye Diseases, Moscow, USSR

    Valentina M. Pantieleva & Alla M. Shapkina

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  1. Valentina M. Pantieleva
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  2. Alla M. Shapkina
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Pantieleva, V.M., Shapkina, A.M. Glucocorticoids and intraocular pressure. Albrecht von Graefes Arch. Klin. Ophthalmol. 199, 303–310 (1976). https://doi.org/10.1007/BF00417301

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  • DOI: https://doi.org/10.1007/BF00417301

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