Summary
Of 20 melanoma patients 85% show a prolonged erythema persistence after a marked test erythema of 8 MED with 300 nm±10 nm (control group only 34%).
This phenomenon does not correlate with the skin type and is useful in identifying high-risk patients prone to melanoma and light-induced skin cancer (92%).
The spontaneous and the UV-C-induced number of sister chromatid exchanges (SCE) per metaphase was significantly higher in peripheral leukocytes of melanoma patients than in normal controls. The attempt was made to establish a “risk-spectrum” of cutaneous melanoma phenotype.
Zusammenfassung
Von 20 Melanompatienten zeigen 85% eine überlange Persistenz eines deutlichen Erythems durch 8 MED mit 300 nm±10 nm (Kontrollgruppe nur 34%). Dieses Phänomen ist nicht mit den Hauttyp korreliert und kann zur prospektiven Identifizierung von Risikopatienten für Melanome und Lichtkarzinome (92%) Anwendung finden.
Die Zahl spontaner und UV-C-induzierter „sister chromatid exchanges” (SCE) pro Metaphase ist in peripheren Leukozyten von Melanompatienten signifikant höher als bei der Kontrolle. Es wird der Versuch formuliert, ein „Risikospektrum” des Melanom-Phänotyps abzustecken.
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References
Abo-Darub JM, Mackie R, Pitts JD (1978) DNA repair deficiency in lymphocytes from patients with actinic keratosis. Bull Cancer 65:357–362
Jung EG, Bohnert E (1979) Lichtbiologie der Haut. In: Jadassohn J (ed) Handbuch der Haut- und Geschlechtskrankheiten, Ergänz-Bd I/4 A. Springer, Berlin Heidelberg New York, pp 459–540
Jung EG, Furtwängler M, Klostermann G, Bohnert E (1980) Light-induced skin cancer and prolonged UV-erythema. Arch Dermatol Res 267:33–36
Lambert B, Ringborg U, Swanbeck G (1976) Ultraviolet-induced DNA repair synthesis in lymphocytes from patients with actinic keratosis. J Invest Dermatol 67:549–598
Ringborg U, Lagerlöf B, Lambert B (1980) Normal UV-induced DNA repair synthesis in peripheral leukocytes from patients with malignant melanoma of the skin. J Invest Dermatol 74:72–73
Sbano E, Andreassi L, Fimiani M, Valentino A, Baiocchi R (1978) DNA repair after irradiation in skin fibroblasts from patients with actinic keratosis. Arch Dermatol Res 262:55–61
Schönwald D, Passarge E (1977) UV-Light-induced SCE in xeroderma pigmentosum lymphocytes. Hum Gen 36:213–218
Tanenbaum L, Parrish JA, Harley AH, Fitzpatrick TB, Pathak MA (1976) Prolonged ultraviolet light-induced erythema and the cutaneous carcinoma phenotype. J Invest Dermatol 67:513–517
Wolff S, Perry P (1974) Differential Giemsa staining of sister chromatids and the study of sister chromatid exchanges without autoradiography. Chromosoma 48:341–353
Zanzoni F, Baumann JWA, Jung EG (1979) Sister chromatid exchange (SCE) in human lymphocytes. Effect of UVC irradiation and age. Arch Dermatol Res 265:283–287
Zanzoni F, Jung EG (1980) Arsenic elevates the sister chromatid exchange, (SCE) rate in human lymphocytes in vitro. Arch Dermatol Res 267:91–95
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Jung, E.G., Günthart, K., Metzger, R.F.G. et al. Risk factors of the cutaneous melanoma phenotype. Arch Dermatol Res 270, 33–36 (1981). https://doi.org/10.1007/BF00417147
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DOI: https://doi.org/10.1007/BF00417147