Advertisement

Acute retrolental fibroplasia

  • R. Y. Foos
Article

Summary

A pathologic analysis of 19 cases of acute retrolental fibroplasia in autopsy eyes from paranatal infants is presented.

The clinical profile of these subjects showed no clear-cut maternal factors. Infant factors included systemic congenital anomalies (14 eases); ocular congenital anomalies (1); birth weight—less than 1500 grams (12), more than 2000 grams (4); neonatal complications—“respiratory distress” (8), “apneic spells” (7), Erythroblastosis fetalis (3); oxygen therapy of varying amounts (14); periodic elevations of arterial oxygen (7); and varying survival times (intrauterine death, one case; less than 48 extrauterine hours, 9 cases).

Considering all cases, the lesions showed a progressive pattern—beginning with proliferation of primitive vascular mesenchyme in vanguard of advancing vasculature (four cases), formation of intraretinal band of endothelial cells in rear guard (10 cases), and finally, extraretinal neovascularization from rear guard zone (five cases).

Keywords

Oxygen Therapy Maternal Factor Neonatal Complication Intrauterine Death Guard Zone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Zusammenfassung

Die Augenbefunde von 19 Fällen akuter retrolentaler Fibroplasie werden nach pathologischem Gesichtspunkt ausgewertet. Die Augen waren bei der Obduktion gewonnen worden.

Die klinischen Befunde ergaben keinen sicheren Anhaltspunkt, wonach ein mütterlicher Faktor eine Rolle spielen könnte. Die Krankenbefunde an den Kindern ergaben folgendes: Geburtsfehler (14 Fälle), angeborene Augenanomalie (1), Geburtsgewicht weniger als 1500 Gramm (12), Geburtskomplikationen, Atemnot (3), Sauerstoffbehandlung in verschiedener Konzentration (14), zeitweilige Erhöhung des arteriellen Sauerstoffes (7) und verschieden lange Überlebenszeit (intrauteriner Tod in einem Fall, Tod in den ersten 48 Std in 9 Fällen).

In allen Fällen zeigte der pathologische Vorgang eine fortschreitende Verschlechterung: Er beginnt mit einer Wucherung primitiven Gewebsmesenchyms in Form einer „Vorhut“ sich vorwärts entwickelnder Gefäße (4 Fälle). Dann entsteht ein Band von Endothelzellen innerhalb der Netzhaut in Form einer „Nachhut“ (10 Fälle) und schließlich bilden sich neue Gefäße außerhalb der Netzhaut von dieser „Nachhutzone“ aus (5 Fälle).

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Addison, D. J., Font, R. L., Manchot, W. A.: Proliferative retinopathy in anencephalic babies. Amer. J. Ophthal. 74, 967 (1972)Google Scholar
  2. Andersen, S. R., Bro-Rasmussen, F., Tygstrup, I.: Anencephaly related to ocular development and malformation. Amer. J. Ophthal. 64, 559 (1967)Google Scholar
  3. Ashton, N.: Pathological basis of retrolental fibroplasia. Brit. J. Ophthal. 38, 385 (1954)Google Scholar
  4. Ashton, N.: Oxygen and the growth and development of retinal vessels. Amer. J. Ophthal. 62, 412 (1966)Google Scholar
  5. Bruckner, H. L.: Retrolental fibroplasia—associated with intrauterine anoxia? Arch. Ophthal. 80, 504 (1968)Google Scholar
  6. Cantolino, S. J., O'Grady, G. E., Herrera, J. A., Israel, C., Justice, J., Flynn, J. T.: Ophthalmoscopic monitoring of oxygen therapy in premature infants. Amer. J. Ophthal. 71, 322 (1971)Google Scholar
  7. Cogan, D. G.: Doyne Memorial Lecture (1963): Development and senescence of the human retinal vasculature. Trans. Ophthal. Soc. U.K. 83, 465 (1963)Google Scholar
  8. DeLeon, A. S., Elliot, J. H., Jones, D. B.: The resurgence of retrolental fibroplasia. Pediat. Clin. N. Amer. 17, 309 (1970)Google Scholar
  9. Foos, R. Y., Kopelow, S. M.: Development of retinal vasculature in paranatal infants. Surv. Ophthal. 18, 117 (1973)Google Scholar
  10. Friedenwald, S. S., Owens, W. C., Owens, E. U.: Retrolental fibroplasia in premature infants. III. The pathology of the disease. Trans. Amer. ophthal. Soc. 49, 207 (1951)Google Scholar
  11. Kalina, R. E.: Ophthalmic examination of children with low birth weight. Amer. J. Ophthal. 67, 134 (1969)Google Scholar
  12. Karlsberg, R. C., Green, W. R., Patz, A.: Congenital retrolental fibroplasia. Arch. Ophthal. 89, 122 (1973)Google Scholar
  13. Majima, A., Takahashi, M., Hibino, Y.: Clinical studies on retinopathy of prematurity. Proceedings of the XXIInd International Congress of Ophthalmology, Paris, France (May 1974), H. Saraux, ed. Amsterdam; Excerpta Medica International Congress (in press)Google Scholar
  14. Nagata, M., Tsurucka, Y.: Treatment of acute retrolental fibroplasia when zenon arc photocoagulation. Proceedings of the XXIInd International Congress of Ophthalmology, Paris, France (May 1974), H. Saraux, fed. Amsterdam: Excerpta Medica International Congress (in press)Google Scholar
  15. Newell F. W., Path, A.: The ophthalmologist in the premature nursery (editorial). Amer. J. Ophthal. 66, 969 (1968)Google Scholar
  16. O'Grady, G. E., Flynn, J. T., Herrera, J. A.: The clinical course of retrolental fibroplasia in premature infants. Sth med. J. (Bgham, Ala.) 65, 655 (1972)Google Scholar
  17. Patz, A.: Retrolental fibroplasia. Surv. Ophthal. 14, (1969)Google Scholar
  18. Reese, A. B., Blodi, F. C., Locke, J. C.: The pathology of early retrolental fibroplasia. Amer. J. Ophthal. 35, 1407 (1952)Google Scholar
  19. Roth, A. M., Foos, R. Y.: A system for macroexamination of eyes in the laboratory. Amer. J. clin. Path. 59, 674 (1973)Google Scholar
  20. Serpell, G.: Polysaccharide granules in association with developing retinal vessels and with retrolental fibroplasia. Brit. J. Ophthal. 38, 460 (1954)Google Scholar
  21. Tasman, W.: Vitreoretinal changes in cicatricial retrolental fibroplasia. Trans. Amer. ophthal. Soc. 68, 548 (1970)Google Scholar
  22. Ward, B. A.: Ocular histology in premature infants with reference to retrolental fibroplasia. Brit. J. Ophthal. 38, 455 (1954)Google Scholar
  23. Zimmerman, L. E.: Further observations on the pathogenesis of congenital glaucoma. Trans. Amer. ophthal. Soc. 60, 140 (1962)Google Scholar

Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • R. Y. Foos
    • 1
  1. 1.The Department of Pathology and the Jules Stein Eye InstituteUCLA School of MedicineLos Angeles

Personalised recommendations