Skip to main content
SpringerLink
Log in

Immunobiology of gonococcal outer membrane protein I

  • Section 3: Outer Membrane Proteins and IgA Protease
  • Published:
Antonie van Leeuwenhoek Aims and scope Submit manuscript

Abstract

Monoclonal antibodies have been obtained which react with gonococcal outer membrane protein I. One antibody recognised the majority of strains expressing P.IA and another recognised the majority of strains expressing P.IB. In in vitro tests both antibodies were bactericidal in the presence of complement, opsonic for phagocytosis by human PMN and protected epithelial cells against gonococcal invasion. Thus conserved epitopes on P.I. are potentially effective targets for immunoprophylaxis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Blake, M. S. (1985) Implications of the active role of gonococcal porins in disease. In: G. Schoolnik (Ed) The Pathogenic Neisseriae (pp. 251–258).

  • Douglas, J. T., M. D. Lee & H. Nikaido (1981) Protein I of Neisseria gonorrhoeae outer membrane is a porin. F.E.M.S. Microbiol. Lett. 12: 305–309

    Google Scholar 

  • Fletcher, J. N., K. Zak, M. Virji & J. E. Heckels (1986) Monoclonal antibodies to gonococcal outer membrane protein I: Location of a conserved epitope on protein IB. J. Gen. Microbiol. 132: 1611–1620

    Google Scholar 

  • Sandstrom, E. G., K. C. S. Chen & T. M. Buchanan (1982) Serology of Neisseria gonorrhoeae: co-agglutination serogroups WI and WII/III correspond to different outer membrane protein molecules. Infect. Immun. 38: 462–470

    Google Scholar 

  • Virji, M. & J. E. Heckels (1985) Role of anti-pilus antibodies in host defence against gonococcal infection studied with monoclonal antipilus antibodies. Infect. Immun. 49: 621–628

    Google Scholar 

  • Virji, M. & J. E. Heckels (1986) The effect of protein II and pili on the interaction of Neisseria gonorrhoeae with human polymorphonuclear leukocytes. J. Gen. Microbiol. 132: 503–512

    Google Scholar 

  • Virji, M., Zak, K. & J. E. Heckels (1986) Monoclonal antibodies to gonococcal outer membrane protein IB: Use in the investigation of the potential protective effect of antibodies directed against conserved and type-specific epitopes. J. Gen. Microbiol. 132: 1621–1629

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dept. of Microbiology, University of Southampton, Medical School, Southampton General Hospital, S09 4XY, Southampton, UK

    J. E. Heckels, M. Virji, K. Zak & J. N. Fletcher

Authors
  1. J. E. Heckels
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Virji
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K. Zak
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. N. Fletcher
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Heckels, J.E., Virji, M., Zak, K. et al. Immunobiology of gonococcal outer membrane protein I. Antonie van Leeuwenhoek 53, 461–464 (1987). https://doi.org/10.1007/BF00415503

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00415503

Keywords

Search

Navigation