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Untersuchung des Knochenstoffwechsels transplantierter Mäusetibiae in Abhängigkeit vom Alter der Empfängertiere mit Hilfe von 85Sr

Influence of age of the recipient on 85Sr uptake of tibia transplants in mice

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Archiv für orthopädische und Unfall-Chirurgie, mit besonderer Berücksichtigung der Frakturenlehre und der orthopädisch-chirurgischen Technik Aims and scope Submit manuscript

Summary

The 85Sr retention of syngeneic and allogeneic tibia grafts taken from 16-day-old mice was investigated using recipients of 16 days, 12 weeks and 1 year of age. 85Sr retentions of syngeneic grafts of the tibia were generally higher than those of allogeneic ones. Additionally, there was in all grafts an increased 85Sr uptake with increasing age of the recipients. Simultaneously an increased excretion of 85Sr was observed in the older recipients. This finding may be explained by the decreasing uptake of 85Sr by the whole skeleton of the older recipients, which was recorded by the decreasing 85Sr uptake of recipient tibiae, leaving more 85Sr in the common pool to be taken up by the grafts or to be excreted. However, the proportion of 85Sr uptake of syngeneic and allogeneic grafts was also changed with age of the recipients, leading to a decrease of the ratio 85Sr in syngeneic grafts versus 85Sr in allogeneic grafts of older recipients. This points to a decrease of the immunological response with increasing age of the recipients.

Zusammenfassung

Untersucht wurde die 85Sr-Retention syngener und allogener Tibiatransplantate, die auf Empfängertiere unterschiedlichen Alters transplantiert worden waren. Während die 85Sr-Retentionen der syngenen Transplantate übereinstimmend bei den verschieden alten Empfängertieren einige Tage nach der Transplantation anstiegen, ein Maximum durchliefen und dann wieder abfielen, blieb der 85Sr-Gehalt bei den allogenen Transplantaten während der gesamten Versuchsdauer gleich niedrig. Das Alter der Empfängertiere beeinflußt die 85Sr-Retentionen der Transplantate über zwei verschiedene Vorgänge. Erstens akkumuliert das Skelet älterer Tiere weniger 85Sr, so daß es zu einer höheren Anreicherung von Radiostrontium im Transplantat sowie zu einer erhöhten Exkretion von 85Sr kommt. Zweitens wird mit zunehmendem Alter der Empfängertiere das Verhältnis der 85Sr-Retentionen der syngenen zu den allogenen Transplantaten (R syn /R all ) kleiner, was als Folge einer Minderung der Immunreaktion bei alten Empfängertieren gedeutet wird.

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  1. Abteilung für Nuklearbiologie, Gesellschaft für Strahlen- und Umweltforschung mbH, Ingolstädter Landstraße 1, D-8042, Neuherberg

    R. Märkl & W. E. Kollmer

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  1. R. Märkl
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  2. W. E. Kollmer
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Märkl, R., Kollmer, W.E. Untersuchung des Knochenstoffwechsels transplantierter Mäusetibiae in Abhängigkeit vom Alter der Empfängertiere mit Hilfe von 85Sr. Arch orthop Unfall-Chir 86, 77–83 (1976). https://doi.org/10.1007/BF00415305

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  • DOI: https://doi.org/10.1007/BF00415305

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