Summary
Estrone and estradiol-17β were incubated with various eye tissues of female rabbits. The interconversion of both estrogenes by the action of 17β-hydroxysteroid dehydrogenase decreased in the sequence cornea, iris, retina, and lens. In a smaller yield estradiol-17α was also formed from estrone.
The cornea seems to be an active estrogen-metabolizing tissue. The role of estrogens and progestogens in the tissues of the anterior eye segment is briefly discussed.
Zusammenfassung
Östron und Östradiol-17β wurden mit verschiedenen Augengeweben weiblicher Kaninchen bebrütet. Die Wechselkonversion beider Östrogene durch die Wirkung der 17β-Hydroxysteroid Dehydrogenase sank in der Reihenfolge: Hornhaut, Regenbogenhaut, Linse und Netzhaut. In wesentlich geringerem Umfang wurde aus Östron auch östradiol17-α gebildet.
Die Hornhaut ist offenbar das aktivste Gewebe beim Östrogenstoffwechsel im Auge. Die Rolle der Östrogene und der Gestagene am vorderen Augenabschnitt wird kurz besprochen.
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References
Brown, J. B.: A chemical method for the determination of oestriol, oestrone and oestradiol in human urine. Biochem. J. 60, 185–191 (1955)
Brown, S. I., Weller, C. A., Vidrich, A.: The effect of corticosteroids on corneal collagenase. Amer. J. Ophthal. 70, 744–747 (1970)
Corcelle, L.: Auge und Pille. Klin. Mbl. Augenheilk. 163, 204–211 (1973)
Davidson, S. I.: Reported adverse effects of oral contraceptives on the eye. Trans. ophthal. Soc. U.K. 91, 561–573 (1971)
Epifanova, O. I.: Gormony i raznmozhenie kletok (Hormones and cell reproduction), Nauka, Moskva 1965
François, J., Victoria-Troncoso, V.: Mucopolysaccharides et hypertension oculaire. (Pathogenie du glaucome cortisonique.) Ann. Oculist. (Paris) 207, 625–641 (1974)
François, J., Victoria-Troncoso, V.: Mukopolysaccharide und Pathogenese kortisonbedingter Augendrucksteigerung. Klin. Mbl. Augenheilk. 165, 5–10 (1974)
Friedburg, D.: NAD-spezifische Isoeitrat-Dehydrogenase, ein Indicatorenzym für oxidative Stoffwechselprozesse im Linsenepithel. Albrecht v. Graefes Arch. klin. exp. Ophthal. 175, 131–135 (1968)
Gross, J.: Collagen biology. Structure, degradation and disease. In: The Harvey Lectures, Harvey Society of New York, 1972–1973, p. 351–432. New York: Academic Press 1974
Hervonen, A., Kanerva, L., Lietzén, R.: Histochemically demonstrable catecholamines and cholinesterases of the rat uterus during estrus cycle, pregnancy and after estrogen treatment. Acta physiol. scand. 87, 283–288 (1973)
Hollwich, F., Verbeck, B.: Nebenwirkungen der Ovulationshemmer am Auge. Dtsch. med. Wschr. 94, 1761–1765 (1969)
Jonek, J., Konecki, J., Chojnacka-Konecka, R.: The influence of estrogens on the DNA synthesis in the corneal epithelium. [In Polish.] Ginek. pol. 38, 117–123 (1967)
Knuppen, R.: Papierchromatographie phenolischer Steroide. Z. Vitamin-, Hormon- u. Fermentforsch. 12, 355–401 (1962/63)
Kuk, J. F. R. Jr.: Metabolism of the lens. In: Biochemistry of the eye, edit. by C. N. Graymore, p. 277. London and New York: Academic Press 1970
Lambert, B. W.: Effects of progestins and estrogens on the permeability of the lens. Arch. Ophthal. (Chic.) 80, 230–234 (1968)
Leach, N., Wallis, N., Lothringer, L. L., Olson, J.: Corneal hydration changes during the normal menstrual cycle—a preliminary study. J. reproduct. Med. 6, 201–204 (1971)
Lee, P. F., Donovan, R. H., Mukai, N.: Effects of Norethynodrel with Mestranol on the rabbit eye. Arch. Ophthal. (Chic.) 81, 89–98 (1969)
Millodot, L. M., Lamont, A.: Influence of menstruation on corneal sensitivity. Brit. J. Ophthal. 58, 752–756 (1974)
Nozawa, S., Kurihara, S., Tsutsui, F., Watanabe, K.: The effect of oestrogens on the lysosomes of rat vaginal epithelium: A histochemical study. Acta endocr. (Kbh.) 77, 193–208 (1974)
Obenberger, J., Babický, A., Ošťádalová, I.: Study of corneal hydration and corneal uptake of 35S and 45Ca in rats after administration of a single dose of estrogens during the first days of postnatal life. Albrecht v. Graefes Arch. klin. exp. Ophthal. 191, 85–91 (1974)
Platt, D., Eimer, H.: Aktivitätsmessungen lysosomaler Enzyme im menschlichen Serum nach Gabe von hormonalen Kontrazeptiva. Klin. Wschr. 51, 91–92 (1973)
Ryan, J. N., Woessner, J. F. Jr.: Oestradiol inhibition of collagenase role in uterine involution. Nature (Lond.) 248, 526–528 (1974)
Sabell, A. G.: Oral contraceptives and the contact lens wear. Brit. J. physiol. Opt. 25, 127–137 (1970)
Stárka, L., Obenberger, J., Hampl, R., Kudová, M.: Identification of endogenous sexual hormones in the aqueous humour of the rabbit eye. (Prepared for publication)
Suprun, A. V., Rudinskaya, G. M.: Glaucoma and symptomatic hypertension in women during climacterium. [In Russian.] Vestnik Oftal., No. 1, 3–6 (1974)
Tomkins, G. M., Maxwell, E. S.: Some aspects of steroid hormone action. Ann. Rev. Endocr. 32, 677–708 (1963)
Varga, M.: Ophthalmologische Komplikationen nach oraler Kontrazeption. Klin. Mbl. Augenheilk. 162, 621–629 (1973)
Verbeck, B.: Augenbefunde und Stoffwechselverhalten bei Einahme von Ovulationshemmern. Klin. Mbl. Augenheilk. 162, 612–621 (1973)
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Stárka, L., Obenberger, J. In vitro estrone-estradiol-17β interconversion in the cornea, lens, iris and retina of the rabbit eye. Albrecht von Graefes Arch. Klin. Ophthalmol. 196, 199–204 (1975). https://doi.org/10.1007/BF00414806
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DOI: https://doi.org/10.1007/BF00414806