Summary
Authors examined the role of the cellular immunity by the method (I) of lymphoblastic transformation in 26 keratoplasty cases. Only in one case did they observe significant blast transformation, in this case the keratoplasty was necessary after injury with lime. In the rest of the cases no positive result were ever obtained.
They investigated the cellular immunoreactivity of 10 patients waiting for keratoplasty and 10 cataractous patients against cornea antigen by means (II) of the Leucocyte Migration Test (LMT).
The change of the cellular immuno-reactivity against cornea antigen was examined on the 1st, 4th, 7th, 14th, 21st, and 28th days after keratoplasty. It could be estabilished that after keratoplasty the LMT became positive (inhibition or stimulation of migration).
The results of the LMT investigations obtained on keratoplasty patients by cornea antigen may be of some help for the understanding of the events in the postoperative phase and sometimes also may eventually require immunosuppressive therapy.
Zusammenfassung
Die Autoren untersuchten in 26 Keratoplastik-Fällen die Rolle der cellulären Immunität mittels der Methode (I) der lymphoblastischen Transformation. In nur einem Fall konnte eine signifikante Blast-Transformation beobachtet werden, es handelte sich um einen Zustand nach Kalkverätzung. In den übrigen Fällen waren die Resultate negativ.
Außerdem wurde bei 10 auf Keratoplastik wartenden Patienten und 10 Patienten mit Katarakt die celluläre Immunreaktion gegen Cornealantigen mit Hilfe des (II) Migrationstestes der Leukocyten (LMT) untersucht.
Die Veränderung der cellulären Immun-Reaktion gegen Hornhaut-Antigen wurde verschieden lange nach der Keratoplastik untersucht. Dabei konnte nachgewiesen werden, daß der LMT nach Keratoplastik positiv wurde (Inhibition oder Stimulation der Migration).
Die bei Keratoplastik-Patienten durch die mit kornealem Antigen erhaltenen Resultate der LMT-Untersuchungen könnten in gewissem Sinne zum Verständnis der Vorgänge in der postoperativen Phase beitragen und auch zu einer eventuell notwendig werdenden immunosuppressiven Therapie Anlaß geben.
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Szabó, G., Balázs, C., Leövey, A. et al. Immunological investigations of patients with transplanted cornea. Albrecht von Graefes Arch. Klin. Ophthalmol. 196, 169–179 (1975). https://doi.org/10.1007/BF00414803
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DOI: https://doi.org/10.1007/BF00414803