Skip to main content
SpringerLink
Log in

Klinik und Morphologie kindlicher Rhabdomyosarkome der Orbita

Orbital rhabdomyosarcoma. Clinicopathological study of 7 cases including electron microscopy and survey of the literature

  • Published:
Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie Aims and scope Submit manuscript

Summary

The clinical course of orbital rhabdomyosarcoma is described in seven male children. A survey of the literature on the subject is given. Particular attention is paid to certain diagnostic problems of this most frequent orbital malignant primary in childhood. An adequate combination therapy which results in cure in more than half of the patients should be employed provided that an exact morphological diagnosis is made; this still causes often great difficulty. Electron microscopy is of great value in distinguishing this type of tumor from other malignancies, including the so-called reticulosarcoma. In comparison with the case material of other authors, there was a relatively high rate of late deaths in our patients.

Zusammenfassung

Es wird über die Krankheitsverläufe bei 7 Knaben mit primärem Rhabdomyosarkom der Orbita berichtet und eine Übersicht über diesen häufigsten malignen Orbitatumor im Kindesalter gegeben. Auf die besondere diagnostische Problematik wird eingegangen. Eine exakte morphologische Diagnose, die gegenwärtig beim Rhabdomyosarkom vielfach noch auf erhebliche Schwierigkeiten stößt, ist Voraussetzung einer adäquaten Kombinationstherapie, die Heilungen in mehr als der Hälfte der Fälle ermöglicht. In diesem Zusammenhang wird auf den großen Wert der Elektronenmikroskopie für die Abgrenzung dieser Malignome von anderen Malignomen einschließlich des sog. Retikulosarkoms hingewiesen. Im Vergleich zu den Erhebungen anderer Autoren fällt bei den eigenen Patienten die relativ hohe Rate später Todesfälle auf.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literatur

  1. Ashton, N., Morgan, G.: Embryonal sarcoma and rhabdomyosarcoma of the orbit. J. clin. Path. 18, 699 (1965)

    Google Scholar 

  2. Bässler, R., Voth, D.: Pathologie und submikroskopische Morphologie des sogenannten Sarcoma botryoides der großen Gallengänge. Z. Krebsforsch. 65, 44 (1962)

    Google Scholar 

  3. Caffey, J., Anderson, D. H.: Metastatic embryonal rhabdomyosarcoma in the growing skeleton. Amer. J. Dis. Child. 95, 581 (1958)

    Google Scholar 

  4. Cassady, J. R., Sagerman, R. H., Tretter, P., Ellsworth, R. M.: Radiation therapy for rhabdomyosarcoma. Radiology 91, 116 (1968)

    Google Scholar 

  5. Shapman, G. B., Jones, I. S., Spelsberg, W. W.: An electron microscope study of rhabdomyosarkoma. Invest. Ophthal. 2, 538 (1963)

    Google Scholar 

  6. Dito, W. R., Batsakis, J. G.: Rhabdomyosarcoma of the head and neck. An appraisal of the biologic behaviour in 170 cases. Surgery 84, 112 (1962)

    Google Scholar 

  7. Donaldson, S. S., Castro, J. H., Wilbur, J. R., Jesse, R. H.: Rhabdomyosarcoma of the head and neck in children. Combination treatment by surgery, irradiation, and chemotherapy. Cancer (Philad.) 31, 26 (1973)

    Google Scholar 

  8. Ehrlich, F. E., Haas, J. E., Kiesewetter, W. B.: Rhabdomyosarcoma in infants and children: factors affecting long-term survival. J. Pediat. Surg. 6, 771 (1971)

    Google Scholar 

  9. Enzinger, F. M., Shiraki, M.: Alveolar rhabdomyosarcoma. An analysis of 110 cases. Cancer (Philad.) 24, 18 (1969)

    Google Scholar 

  10. Evans, W.: Histological appearances of tumours. Edinburgh and London: Livingstone Ltd. 1968

    Google Scholar 

  11. Gutjahr, P., Hill, K., Pippert, P., Hofmann, S., Neidhardt, M.: Rhabdomyosarkome im Kindesalter. Mschr. Kinderheilk. 122, 805 (1974)

    Google Scholar 

  12. Henderson, J. W.: Orbital tumors. Philadelphia-London-Toronto: Saunders 1973

    Google Scholar 

  13. Himmel, S., Siegel, H.: Congenital embryonal orbital rhabdomyosarcoma in a newborn. Arch. Ophthal. 77, 662 (1967)

    Google Scholar 

  14. Hogan, N. J., Zimmerman, L. E.: Ophthalmic pathology. Philadelphia-London: Saunders 1962

    Google Scholar 

  15. Horvat, B., Caines, M., Fisher, E.: The ultrastructure of rhabdomyosarcoma. Amer. J. clin. Path. 53, 555 (1970)

    Google Scholar 

  16. Jones, I. S., Reese, A. B., Krout, J.: Orbital rhabdomyosarcoma: an analysis of sixtytwo cases. Trans. Amer. ophthal. Soc. 63, 223 (1965)

    Google Scholar 

  17. Kilman, J. W., Clatworthy, H. W., Newton, W. A., Grosfeld, J. L.: Reasonable surgery for rhabdomyosarcoma. Ann. Surg. 178, 346 (1973)

    Google Scholar 

  18. Kroll, A. J., Kuwabara, T., Howard, G. M.: Electron microscopy of rhabdomyosarcoma of the orbit. Invest. Ophthal. 2, 523 (1963)

    Google Scholar 

  19. Kroll, A. J.: Fine-structural classification of orbital rhabdomyosarcoma. Invest. Ophthal. 6, 53 (1967)

    Google Scholar 

  20. Li, F. P., Fraumeni, J. F.: Rhabdomyosarcoma in children: epidemiologic study and identification of a familial cancer syndrome. J. nat. Cancer Inst. 43, 1365 (1969)

    Google Scholar 

  21. Marsden, H. B., Stewart, J. K.: Tumours in children. Berlin-Heidelberg-New York: Springer 1968

    Google Scholar 

  22. Masson, J. E., Soule, E. H.: Embryonal rhabdomyosarcoma of the head and neck; report of eighty-eight cases. Amer. J. Surg. 110, 585 (1965)

    Google Scholar 

  23. Moore, I., Grossi, C.: Embryonal rhabdomyosarcoma of the head and neck. Cancer (Philad.) 12, 69 (1959)

    Google Scholar 

  24. Morales, A. R., Fine, G., Horn, R. C., Jr.: Rhabdomyosarcoma: an ultrastructural appraisal. In: Sommers, S. C. (Hrsg.), Pathology Annual, Bd. 7, S. 81. New York: Appleton-Century-Crofts, Meredith Corp. 1972

    Google Scholar 

  25. Naumann, G., Font, R. L., Zimmerman, L. E.: Electron microscope verification of primary rhabdomyosarcoma of the iris. Amer. J. Ophthal. 74, 110 (1972)

    Google Scholar 

  26. Nover, A.: Orbita-Tumoren bei Kindern. Z. Kinderheilk. 100, 343 (1967)

    Google Scholar 

  27. Pinkel, D., Pickren, J.: Rhabdomyosarcoma in children. J. Amer. med. Ass. 175, 293 (1961)

    Google Scholar 

  28. Plüss, H. J., Johnson, W. W.: Zur Diagnostik der Rhabdomyosarkome. Vortr. bei der gemeins. Jahresversammlg. der Schweiz. Ges. Päd. u. der Schweiz. Ges. Kinderchirurgie, Genf 1973

  29. Pochedly, C.: Rhabdomyosarcoma. In: Pochedly, C., Necheles, T. F. (Hrsg.), Major problems in childhood cancer, S. 192–233. Springfield: Thomas 1973

    Google Scholar 

  30. Porterfield, J. F., Zimmerman, L. E.: Rhabdomyosarcoma of the orbit; a clinicopathologic study of 55 cases. Virchows Arch. path. Anat. 335, 329 (1962)

    Google Scholar 

  31. Pratt, C. B., Hustu, H. O., Fleming, I. D., Pinkel, D.: Coordinated treatment of childhood rhabdomyosarcoma with surgery, radiotherapy, and combined chemotherapy. Cancer Res. 32, 606 (1972)

    Google Scholar 

  32. Ragab, A. H., Vietti, R. J., Perez, C. A., Berry, D. H.: Malignant tumors of the soft tissues. In: Sutow, W. W., Vietti, T. J., Fernbach, D. J. (Hrsg.), Clinical pediatric oncology, S. 450–472. St. Louis (Miss.): Mosby 1973

    Google Scholar 

  33. Sagermann, R. H., Tretter, P., Ellsworth, R. M.: The treatment of orbital rhabdomyosarcoma of children with primary radiation therapy. Amer. J. Roentgenol. 114, 31 (1972)

    Google Scholar 

  34. Sarkar, K., Tolnai, G., McKay, D. E.: Embryonal rhabdomyosarcoma of the prostate. An ultrastructural study. Cancer (Philad.) 31, 442 (1973)

    Google Scholar 

  35. Schuster, S. A. D., Ferguson III, E. C., Marshall, R. B.: Alveolar rhabdomyosarcoma of the eyelid. Diagnosis by electron microscopy. Arch. Ophthal. 87, 646 (1972)

    Google Scholar 

  36. Soule, E. H., Mahour, G. H., Mills, S. D., Lynn, H. B.: Soft-tissue sarcomas in infants and children: a clinicopathological study of 135 Cases. Mayo Clin. Proc. 43, 313 (1968)

    Google Scholar 

  37. Spaeth, E. B., Cleveland, A. F.: Rhabdomyosarcoma in infancy and childhood. Amer. J. Ophthal. 53, 463 (1962)

    Google Scholar 

  38. Sutow, W. W., Sullivan, M. P., Ried, H. K., Taylor, H. G., Griffith, K. M.: Prognosis in childhood rhabdomyosarcoma. Cancer (Philad.) 25, 1384 (1970)

    Google Scholar 

  39. Toker, C.: Embryonal rhabdomyosarcoma; an ultrastructural study. Cancer (Philad.) 21, 1164 (1968)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Kinderklinik der Universität Mainz, Bundesrepublik Deutschland

    P. Gutjahr, L.-D. Leder, H.-K. Müller-Hermelink & A. Nover

  2. Pathologisches Institut der Universität Kiel, Bundesrepublik Deutschland

    P. Gutjahr, L.-D. Leder, H.-K. Müller-Hermelink & A. Nover

  3. Universitäts-Augenklinik Mainz, Bundesrepublik Deutschland

    P. Gutjahr, L.-D. Leder, H.-K. Müller-Hermelink & A. Nover

Authors
  1. P. Gutjahr
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L.-D. Leder
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H.-K. Müller-Hermelink
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Nover
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gutjahr, P., Leder, LD., Müller-Hermelink, HK. et al. Klinik und Morphologie kindlicher Rhabdomyosarkome der Orbita. Albrecht von Graefes Arch. Klin. Ophthalmol. 196, 113–126 (1975). https://doi.org/10.1007/BF00414797

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00414797

Key Words

Search

Navigation