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Pressure lowering effect of timolol with reference to its topical vascular action

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Abstract

The hemodynamic effect of timolol maleate in open angle glaucoma was studied rheo-oculographically.

Increase in the ocular pulse which reaches maximal amplification 2 h after the instillation of the drug was observed.

The maximal pressure lowering effect appeared 3 h after instillation, as if the hemodynamic effect were the trigger for the pressure lowering effect.

Zusammenfassung

Mit der rheo-okulographischen Methode untersuchten die Verff. die haemo-dynamische Wirkung des Timolol-Maleats bei Glaukom mit offenem Kammerwinkel.

Sie konnten in allen Fällen eine Zunahme des Augenpulses beobachten, dessen größter Ausschlag 2 h nach Instillierung des Mittels auftrat.

Die größte druckherabsetzende Wirkung wurde erst nach 3 h festgestellt, als ob die haemo-dynamische Wirkung den Trigger für den druckherabsetzenden Effekt darstellte.

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Authors and Affiliations

  1. Clinica Oculistica, Universita' degli Studi di Bologna, Via Massarenti, 9, Bologna, Italy

    G. Cristini & A. Giovannini

Authors
  1. G. Cristini
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  2. A. Giovannini
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Cristini, G., Giovannini, A. Pressure lowering effect of timolol with reference to its topical vascular action. Albrecht von Graefes Arch. Klin. Ophthalmol. 211, 325–328 (1979). https://doi.org/10.1007/BF00414691

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  • DOI: https://doi.org/10.1007/BF00414691

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