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The significance of tears' lactate dehydrogenase in health, and external eye diseases

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Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie Aims and scope Submit manuscript

Summary

The normal values of the lactate dehydrogenase contents of tears in the presence of pyruvate and lactate as substrates were determined. The quotients of the LDH values measured in the presence of the two different substrates, and also the ratio of the subunits (H and M) of the isoenzymes, differ from the corresponding data of blood serum.

In the event of external inflammatory diseases of the eye, LDH p /LDH j decreases in the tears; this deviation is enhanced by treatment with drugs inhibiting protein synthesis, primarily iododeoxyuridine. Conversely, in trachoma the ratio of the LDH isoenzymes containing mainly M (muscle) subunits are increasing.

In diabetes mellitus the shift of metabolism toward the citrate cycle is reflected to a larger extent by the LDH values in the blood serum than by those in tears.

Zusammenfassung

Die Normalwerte für den Gehalt der Tränen an Milchsäuredehydrogenase (LDH) wurden mit der Anwendung der Substrate Pyruvat und Laktat bestimmt. Die hierbei gefundenen Quotienten und die Raten der Untereinheiten (H und M) der Isoenzyme zeigen Unterschiede zu den entsprechenden Daten im Blutserum. — Bei Entzündungen des äußeren Auges nehmen LDH p /LDH j in der Tränenflüssigkeit ab. Diese Abnahme wird durch Behandlung mit Medikamenten, welche die Eiweißsynthese hemmen, speziell mit Joddesoxyuridin (IDU) noch weiter gefördert. Zum Unterschied davon steigen beim Trachom die Werte für die LDH-Isoenzyme, welche hauptsächlich M (Muskel)-Untereinheiten enthalten, an. — Beim Diabetes mellitus kommt die Änderung des Stoffwechsels in die Richtung des Citrat-Cyclus in den LDH Werten des Blutes eher zum Ausdruck als in jenen der Tränenflüssigkeit.

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Authors and Affiliations

  1. University Eye Clinic, Szeged

    Ilona L. Kahán & Eva Ottovay

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  1. Ilona L. Kahán
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  2. Eva Ottovay
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Kahán, I.L., Ottovay, E. The significance of tears' lactate dehydrogenase in health, and external eye diseases. Albrecht von Graefes Arch. Klin. Ophthalmol. 194, 267–276 (1975). https://doi.org/10.1007/BF00414674

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  • DOI: https://doi.org/10.1007/BF00414674

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