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Retinal pigment epithelial degeneration, partial retinal atrophy and macular hole in acute lymphocytic leukemia

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Summary

A seven year old child with acute lymphocytic leukemia presented at autopsy with a macular hole, and degeneration of the retinal pigment epithelium and its overlying photoreceptors. She had been treated with cobalt 60, methotrexate, vincristine cyclophosphamide and prednisone. A review of the literature of similar findings as well as pigment epithelial degenerations from other causes is presented.

Zusammenfassung

Ein 7jähriges Kind mit akuter lymphatischer Leukämie zeigte bei der Obduktion ein Makulaloch mit Degeneration des Netzhautpigmentepithels und der darüberliegenden Zapfen und Stäbchen. Es war mit radio-aktivem Kobalt, Methotrexate, Vinkristin und Prednison behandelt worden. Ähnliche Fälle und Pigmentepitheldegenerationen, durch andere Ursachen hervorgerufen, werden erörtert.

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Authors and Affiliations

  1. Department of Ophthalmology, Albert Einstein College of Medicine/Montefiore Hospital and Medical Center, 10467, Bronx, New York

    David M. Inkeles & Alan H. Friedman

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  1. David M. Inkeles
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  2. Alan H. Friedman
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This work was supported by Grant EY-00613-04 from the National Institutes of Health.

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Inkeles, D.M., Friedman, A.H. Retinal pigment epithelial degeneration, partial retinal atrophy and macular hole in acute lymphocytic leukemia. Albrecht von Graefes Arch. Klin. Ophthalmol. 194, 253–261 (1975). https://doi.org/10.1007/BF00414672

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  • DOI: https://doi.org/10.1007/BF00414672

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