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Use of platelet-fibrinogen-thrombin mixture to seal experimental penetrating corneal wounds

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Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie Aims and scope Submit manuscript

Summary

A platelet-fibrinogen-thrombin mixture utilizing autologous platelets was studied for its potential to seal perforating corneal wounds. In rabbits, the mixture demonstrated sufficient adhesive properties to permit 75% of penetrating keratoplasties to remain in place without the use of sutures. All 12 grafts held initially; after 48 h three grafts extruded. In control eyes only two out of 12 (16%) of the corneal grafts remained in place. The material is simple to prepare and apply and is not toxic to the cornea. It does not cause inflammation or lid irritation. Intraocular complications observed with its use were transient anterior synechiae and retrocorneal membrane formation.

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References

  • Boruchoff, A.A., Refojo, M., Slansky, H.H., Webster, R.G., Jr., Freeman, M.I., Dohlman, C.H.: Clinical applications of adhesives in corneal surgery. Trans. Am. Acad. Ophthalmol. and Otolaryngol. 73, 499–505 (1969)

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Authors and Affiliations

  1. The Division of Ophthalmology and The Department of Medicine, Stanford University Medical Center, 94305, Stanford, California, USA

    A. Ralph Rosenthal, Peter R. Egbert, Christina Harbury, Jerry L. Hopkins & Edward Rubenstein

Authors
  1. A. Ralph Rosenthal
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  2. Peter R. Egbert
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  3. Christina Harbury
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  4. Jerry L. Hopkins
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  5. Edward Rubenstein
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Additional information

Read, in part, before the Western Section, Association for Research in Vision and Ophthalmology, Portland, Oregon, September 18, 1975

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Rosenthal, A.R., Egbert, P.R., Harbury, C. et al. Use of platelet-fibrinogen-thrombin mixture to seal experimental penetrating corneal wounds. Albrecht von Graefes Arch. Klin. Ophthalmol. 207, 111–115 (1978). https://doi.org/10.1007/BF00414308

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  • DOI: https://doi.org/10.1007/BF00414308

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