Summary
In a controlled clinical study, 42 patients with dendritic keratitis were treated either with thermocautery plus human leukocyte interferon (HLI) or with minimal wiping debridement plus HLI. The results show that the efficiency with which primary debridement was carried out, determined the success of further therapy using interferon. We conclude that interferon works basically as a prophylactic agent and needs the support of further antiviral measures to be effective against dendritic keratitis.
Zusammenfassung
42 Patienten mit Keratitis dendritica wurden in einer kontrollierten Studie entweder mit einer Kombination aus Thermokauterung plus Humanleukozyteninterferon (HLI) oder mit einer Kombination behandelt, bei der vor der HLI-Therapie nur eine weniger effektive Wischabrasio durchgeführt wurde. Die Ergebnisse zeigen, daß der Wirkungsgrad des Interferons unmittelbar von der Gründlichkeit der vorhergehenden Abrasio abhängt. Hieraus schließen wir, daß Interferon klinisch im wesentlichen als antivirales Prophylaktikum wirkt und daß es zusätzlicher antiviraler Maßnahmen bedarf, damit Interferon die Heilung einer Keratitis dendritica beschleunigt.
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Reference
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This investigation was supported by the Deutsche Forschungsgemeinschaft
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Sundmacher, R., Cantell, K., Haug, P. et al. Role of debridement and interferon in the treatment of dendritic keratitis. Albrecht von Graefes Arch. Klin. Ophthalmol. 207, 77–82 (1978). https://doi.org/10.1007/BF00414304
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DOI: https://doi.org/10.1007/BF00414304