, Volume 28, Issue 1, pp 95–102 | Cite as

Effect of cannabidiol and of other Cannabis sativa compounds on hippocampal seizure discharges

  • Iván Izquierdo
  • Otto A. Orsingher
  • Antonio C. Berardi
Animal Studies


The natural Cannabis sativa compounds, cannabidiol, cannabinol, δ9- and δ8-tetrahydrocannabinol, in that order of potency, decreased the susceptibility of rat dorsal hippocampus to seizure discharges caused by afferent stimulation. The drugs were effective following both intraperitoneal injection and topical application. They were more active, on a dose basis, than the well-known antiepileptic agents mysoline and diphenylhidantoin. Within the dose range effective in depressing hippocampal seizures, they had no effect on hippocampal evoked responses. This suggested that they might act by interfering with K+ release from hippocampal cells, which is known to be the causative factor in hippocampal seizures. This point was investigated using cannabidiol, which was found to effectively block the release of K+ from the hippocampus caused by afferent stimulation.

Key words

Cannabidiol Cannabis Marihuana Potassium Release Hippocampus Hippocampal Seizures Epilepsy 


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Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • Iván Izquierdo
    • 1
  • Otto A. Orsingher
    • 1
  • Antonio C. Berardi
    • 2
  1. 1.Departamento de Farmacología, Facultad de Ciencias QuímicasUniversidad Nacional de CórdobaEstafeta 32, CórdobaArgentina
  2. 2.Setor de Psicofarmacologia, Departamento de Bioquímica e FarmacologiaEscola Paulista de MedicinaSao PauloBrazil

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