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Permeability of Staphylococcus aureus to the sideromycin antibiotic A 22,765

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Zusammenfassung

Das Sideromycin-Antibioticum A 22,765 wird durch Staphylococcus aureus SG 511 gegen ein Konzentrationsgefälle aus dem Medium aufgenommen. Im Gegensatz dazu zeigen A 22,765-resistente Zellen gegenüber diesem Molekül eine äußerst geringe Permeabilität. Ferrioxamin B dringt nur in sehr geringen Mengen in die Zellen ein, antagonisiert jedoch die Permeation von A 22,765. Die Hemmung dieser Permeation durch Ferrioxamin B wird diskutiert.

Summary

The sideromycin antibiotic A 22,765 is taken up from the medium by Staphylococcus aureus SG 511 against a concentration gradient. In contrast to this, A 22,765-resistant cells display an extremely low degree of permeability to the molecule. Ferrioxamine B penetrates the cells in only very minute quantities, but nevertheless antagonises permeation by A 22,765. This permeation-antagonising effect of ferrioxamine B is discussed.

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References

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Authors and Affiliations

  1. Pharmaceutical Division, Biological Research Laboratories of CIBA Limited, Basle, Switzerland

    W. Zimmermann & F. Knüsel

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  1. W. Zimmermann
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  2. F. Knüsel
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Zimmermann, W., Knüsel, F. Permeability of Staphylococcus aureus to the sideromycin antibiotic A 22,765. Archiv. Mikrobiol. 68, 107–112 (1969). https://doi.org/10.1007/BF00413870

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  • DOI: https://doi.org/10.1007/BF00413870

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