Summary
l-cycloserine, a cyclic derivative of O-substituted hydroxylamine, causes the suppression of the conditioned avoidance reaction in the rat.
The subsequent injection of equimolar amounts of pyridoxine hydrochloride is responsible for a complete reversal of this suppression. The suppression of the conditioned response is not observed with the d-isomer of cycloserine.
Isoniazid is a strong antagonist of l-cycoserine.
Changes in the brain level of GABA under several conditions are described. These changes suggest though do not establish a relationship between the block of the conditioned response and the elevation of the aminoacid above its physiological concentration.
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Abbreviations
- ABAT:
-
γ-aminobutyrate-α-keto-glutarate transaminase
- GABA:
-
γ-aminobutyric acid
References
Benigno, P., e P. Monaco: Analisi dell'effetto sedativo esercitato dal l-4-amino-3-isossazolidone. Arch. int. Pharmacodyn. 124, 191–200 (1960).
Bonavita, V., P. Monaco, V. Scardi and P. Scotto: Behavioural, electrophysiological and neurochemical changes after l-cycloserine. Arch. int. Pharmacodyn. (in press).
Cook, L., and E. Weidley: Behavioural effects of some psychopharmacological agents. Ann. N. Y. Acad. Sci. 66, 740–752 (1957).
Courvoisier, S., J. Fournel, R. Ducrot, M. Kolsky et P. Koetschet: Propriétés pharmacodynamiques du chlorhydrate de chloro-3-(diméthylamino3′propil)-10-phénothiazine (4560 R.P.). Arch. int. Pharmacodyn. 92, 305–361 (1953).
Killam, K. F., S. R. Dasgupta and E. K. Killam: Studies of the action of convulsant hydrazides as vitamin B6 antagonists in the central nervous system. In: Inhibition in the nervous system and gamma-aminobutyric acid, p. 302–316 (ed. by E. Roberts et al.). Oxford: Pergamon Press 1960.
La Grutta, G., et P. Monaco: Mécanisme de l'action centrale de la l-cyclosérine. Arch. int. Pharmacodyn. 135, 187–196 (1962).
Monaco, P.: Le azioni neurofarmacologiche del 4-amino-3-isossazalidone. In: Neuro-Psychopharmacology (ed. by P. B. Bradley et al.), p. 378–380. Amsterdam: Elsevier Publ. Co. 1959.
Moore, S., and W. H. Stein: A modified ninhydrin reagent for the photometric determination of amino acids and related compounds. J. biol. Chem. 211, 907–913 (1954).
Sandman, R. P.: The determination of γ-aminobutyric acid in brain. Analyt. Biochem. 3, 158 (1962).
Scotto, P., P. Monaco, V. Scardi and V. Bonavita: Neurochemical studies with l-cycloserine, a central depressant agent. J. Neurochem. 10, 831–839 (1963).
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Bonavita, V., Lettieri, M. & Monaco, P. Behavioural studies on rats injected with l-cycloserine and other compounds. Psychopharmacologia 5, 234–238 (1964). https://doi.org/10.1007/BF00413246
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DOI: https://doi.org/10.1007/BF00413246