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Behavioural studies on rats injected with l-cycloserine and other compounds

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Summary

l-cycloserine, a cyclic derivative of O-substituted hydroxylamine, causes the suppression of the conditioned avoidance reaction in the rat.

The subsequent injection of equimolar amounts of pyridoxine hydrochloride is responsible for a complete reversal of this suppression. The suppression of the conditioned response is not observed with the d-isomer of cycloserine.

Isoniazid is a strong antagonist of l-cycoserine.

Changes in the brain level of GABA under several conditions are described. These changes suggest though do not establish a relationship between the block of the conditioned response and the elevation of the aminoacid above its physiological concentration.

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Abbreviations

ABAT:

γ-aminobutyrate-α-keto-glutarate transaminase

GABA:

γ-aminobutyric acid

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Authors and Affiliations

  1. Department of Neurology, University of Palermo, Palermo, Italy

    V. Bonavita, M. Lettieri & P. Monaco

Authors
  1. V. Bonavita
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  2. M. Lettieri
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  3. P. Monaco
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Bonavita, V., Lettieri, M. & Monaco, P. Behavioural studies on rats injected with l-cycloserine and other compounds. Psychopharmacologia 5, 234–238 (1964). https://doi.org/10.1007/BF00413246

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