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Etomidate induced retinal changes

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Abstract

The author examined the effect of etomidate-anaesthesia of one hour duration on the ultrastructure of the retina in animal experiments. Immediately after the exposure only the Müller's cells were moderately damaged. One day following the narcosis more serious pathological changes developed in the external nuclear layer which were partly irreversible. The changes found in the internal nuclear layer were less serious. The structure of the glial cells also altered. In the specimens taken 48 h following the anaesthesia the pathological changes of the neurons regressed to some degree, the Müller's cells reorganised and masses of glycogen accumulated in them. Further studies are needed to explain the eventual retinal toxic effect of this agent.

Zusammenfassung

Die vorliegende Arbeit untersucht den Einfluß einer Etomidate (Hypnomidate®)-Anästhesie auf die Ultrastruktur der Retina im Tierexperiment.

Unmittelbar nach der Exposition gegenüber Etomidate lassen sich nur mäßige Schädigungen in den Müllerschen Zellen nachweisen. Einen Tag nach der Narkose finden sich deutlich ausgeprägtere pathologische Veränderungen in der äußeren nuklearen Schicht, die teilweise irreversibel waren. Die in der inneren nuklearen Schicht gefundenen Veränderungen waren weniger ausgeprägt. Zusätzlich fanden sich auch Veränderungen in der Gliazellstruktur. In den Gewebsproben, die 48 Std nach der Narkose präpariert wurden, waren die Veränderungen in den Neuronen teilweise wieder zurückgebildet und die Müllerschen Zellen reorganisiert mit deutlichen Ansammlungen von Glykogen-Granula in den Müllerschen Zellen. Weitere Studien sind notwendig, um den möglichen toxischen Effekt von Etomidate auf die Retina zu untersuchen.

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Author notes

  1. Magdolna Antal

    Present address: Department of Anaesthesiology and Intensiv Care of “Jahn Ferenc” Hospital, H-1204, Budapest, Köves ut 2-4, Hungary

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  1. Postgraduate Medical School, Clinic of Urology, H-1135, Budapest, Szabolcs u. 35, Hungary

    Magdolna Antal

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Antal, M. Etomidate induced retinal changes. Albrecht von Graefes Arch. Klin. Ophthalmol. 215, 193–201 (1981). https://doi.org/10.1007/BF00413151

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