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Vanilmandelic acid urinary excretion in the diagnosis of retinoblastoma

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Summary

In order to evaluate the validity of an urine spot test for the early diagnosis of retinoblastoma, the urine of 10 patients with this disease was examined. The test is based on the increased excretion of vanilmandelic acid and homovanillic acid in cases of retinoblastoma and neuroblastoma and proved to be usefull in the diagnosis of neuroblastoma. No positive results were obtained in our series of retinoblastoma. Therefore, this method cannot be recommended for the diagnosis of retinoblastoma.

Zusammenfassung

Es wurde die Brauchbarkeit eines Schnelltests in der Frühdiagnostik des Retinoblastoms geprüft. Der Urin von 10 Patienten mit dieser Erkrankung wurde untersucht. Der Test basiert auf der erhöhten Ausscheidung von Vanillinmandelsäure und Homovanillin-Mandelsäure bei Retinoblastom und Neuroblastomerkrankten. In der Neuroblastomdiagnostik wurde die Nützlichkeit des Testes nachgewiesen. Bei unseren Untersuchungen an Retinoblastomen ergab er keine positiven Ergebnisse. Dieser Test kann daher für die Diagnostik des Retinoblastoms nicht empfohlen werden.

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References

  1. Brown, D. H.: The urinary excretion of vanilmandelic acid (VMA) and homovanillic acid (HVA) in children with retinoblastoma. Amer. J. Ophthal. 62, 239–243 (1966)

    Google Scholar 

  2. Evans, A. E.: The Labrosse spot-test: A practical aid in the diagnosis and management of children with neuroblastoma. Pediatrics 47, 913–915 (1971)

    Google Scholar 

  3. Frezotti, R., Guerra, R., Bonani, R.: La escrezione d'ell acido vanilmandelico in due casi di retinoblastoma. Boll. Oculist. 46, 765–771 (1967)

    Google Scholar 

  4. Kontras, S. B.: Urinary excretion of 3-methoxy-4-hydroxy-mandelic acid in children with neuroblastoma. Cancer Chemother. Rep. 16, 443–453 (1962)

    Google Scholar 

  5. Labrosse, E. H.: Biochemical diagnosis of neuroblastoma use of a urine spot test. Proc. Amer. Ass. Cancer Res. 9, 39 (1968)

    Google Scholar 

  6. Reese, A. B.: Tumors of the eye. New York: Hoeber 1963

    Google Scholar 

  7. Williams, C. M., Greer, M.: Homovanillic acid and vanilmandelic acid in diagnosis of neuroblastoma. J. Amer. med. Ass. 183, 836–840 (1963)

    Google Scholar 

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Authors and Affiliations

  1. Universitäts-Augenklinik des Klinikum der Gesamthochschule Essen, Deutschland

    Peter Renelt & Wolfgang Trieschmann

Authors
  1. Peter Renelt
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  2. Wolfgang Trieschmann
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Herrn Prof. H. K. Müller zum 75. Geburtstag gewidmet.

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Renelt, P., Trieschmann, W. Vanilmandelic acid urinary excretion in the diagnosis of retinoblastoma. Albrecht von Graefes Arch. Klin. Ophthalmol. 188, 281–283 (1973). https://doi.org/10.1007/BF00412945

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  • DOI: https://doi.org/10.1007/BF00412945

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