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Circadian rhythms

Before and after removal of both eyes for bilateral retinoblastoma

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Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie Aims and scope Submit manuscript

Summary

The blinded mouse deprived of its eyes by surgery or genetics shows a small yet statistically highly significant period alteration of several circadian rhythms. Such a circadian desynchronization is not found in a child studied (before and) after removal of both eyes for bilateral retinoblastoma. A major role in the synchronization of human rhythms in such a case and others is played by socioecologic factors acting by means not mediated by the eyes (presumably other than the effects of alternating light and darkness).

Zusammenfassung

Nach Entfernung der Augen bei der Maus und bei einigen anderen Lebewesen findet sich eine geringe, jedoch reproduzierbare und statistisch hoch signifikante Veränderung der Periode einiger zirkadianer Rhythmen. Solch eine zirkadiane Desynchronization ließ sich nach Entfernung beider Augen bei einem Kind mit bilateralem Retinoblastom nicht finden. Sozioökologische Synchronisation auf Wegen, die von der Wirkung des Licht-Dunkelwechsels über die Augen unabhängig sind, stellt wohl in solchen Fällen den wichtigen Synchronisator humaner Rhythmen dar.

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Authors and Affiliations

  1. Departments of Medicine and Surgery, New Britain General Hospital, New Britain, Connecticut

    Howard Levine & Daniel Taylor

  2. University of Connecticut Health Center, Hartford, Connecticut

    Howard Levine & Daniel Taylor

  3. Chronobiology Laboratories, Department of Laboratory Medicine and Pathology, University of Minnesota, 55455, Minneapolis, Minnesota

    Franz Halberg

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  1. Howard Levine
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  2. Daniel Taylor
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  3. Franz Halberg
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Additional information

Data Analysis performed in Minnesota was supported by U.S. Public Health Service (5-Kg-Cm-13,981) NASA (NAS 2-2738 and NGE-24-005-006), U.S.Air Force (F 29600-69-C-0011) and Auxiliary New Britain General Hospital.

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Levine, H., Taylor, D. & Halberg, F. Circadian rhythms. Albrecht von Graefes Arch. Klin. Ophthalmol. 188, 263–280 (1973). https://doi.org/10.1007/BF00412944

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