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The influence of catecholamines on the normal and sympathetically decentralized rabbit eye

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Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie Aims and scope Submit manuscript

Summary

  1. 1.

    The influence of intravenously and topically applied catechol-amines on intraocular pressure (IOP) in normal and decentralized eyes was studied in the rabbit.

  2. 2.

    After topical application, adrenaline induced a decrease in IOP. The response was much more pronounced in decentralized eyes, indicating the development of decentralization supersensitivity.

  3. 3.

    The intravenous infusion of noradrenaline (10−5 g·kg−1 · min−1 for 5 min) increased both arterial blood pressure and IOP. The hypertensive response was approximately the same in normal and decentralized eyes. The increase in IOP is probably due to the rise in blood pressure. In this context, there were no signs of supersensitivity after decentralization, indicating that the increase in IOP is not brought about by a direct influence of the drug on the eye itself.

  4. 4.

    The present results once more confirm the opinion that abrupt changes in arterial or venous blood pressure are followed by similar change in IOP.

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References

  • Alphen, G. W. H. N. van, Kern, R., Robinette, S. L.: Adrenergic receptors of the intraocular muscles, comparison to cat, rabbit and monkey. Arch. Ophthal. 74, 253 (1965).

    Google Scholar 

  • Bennett, D. R., Reinke, D. A., Alpert, E., Baum, T., Vasquez-Leon, H.: The action of intraocularly administered drugs on the iris. J. Pharmacol. exp. Ther. 134, 90 (1961).

    Google Scholar 

  • Bettmann, J. W., Fellows, V.: Effect of peripheral vasodilator and vasoconstrictor drugs on the intraocular (choroidal) blood volume. Trans. Amer. Acad. Ophthal. 66, 480 (1962).

    Google Scholar 

  • Eakins, K. E.: The effect of intravitreous injections of norepinephrine and isoproterenol on the intraocular pressure and aqueous humour dynamics of rabbit eyes. J. Pharmacol. exp. Ther. 140, 79 (1963).

    Google Scholar 

  • —, Eakins, H. T. M.: Adrenergic mechanisms and the outflow of aqueous humour from the rabbit eye. J. Pharmacol. exp. Ther. 144, 60 (1964).

    Google Scholar 

  • —, Ryan, S. J.: The action of sympathomimetic amines on the outflow of aqueous humour from the eye. Brit. J. Pharmacol. 23, 374 (1964).

    Google Scholar 

  • Goldmann, H., Schmidt, H.: Weiterer Beitrag zur Applanationstonometrie. Ophthalmologica (Basel) 141, 441 (1961).

    Google Scholar 

  • Kirpekar, S. M., Cervoni, P., Furchgott, R. F.: Catecholamine content of the cat nictitating membrane following procedures sensitizing it to norepinephrine. J. Pharmacol. exp. Ther. 135, 180 (1962).

    Google Scholar 

  • Langham, M. E.: The response of the pupil and intraocular pressure of conscious rabbits to adrenergic drugs following unilateral superior ganglionectomy. Exp. Eye Res. 4, 38 (1965).

    Google Scholar 

  • —, Taylor, C. B.: The influence of pre- and postganglionic section of the cervical sympathetic chain on the intraocular pressure of rabbits and cats. J. Physiol. (Lond.) 152, 437 (1960).

    Google Scholar 

  • Ohnesorge, F. K., Soyka, H., Soyka, H., van Zwieten, P. A.: Über den Einfluß systemisch verabfolgter Catecholamine auf den Augeninnendruck bei Ratten. Albrecht v. Graefes Arch. Ophthal. 173, 241 (1967).

    Google Scholar 

  • Sallmann, L. von, Meyers, M. P., Pillat, B.: Studies on the effect of noradrenaline on the eye. Amer. J. Ophthal. 36, 91 (1953).

    Google Scholar 

  • Schmiedeberg, W., Thiel, H. J., van Zwieten, P. A.: The influence of drugs involved in general anaesthesia and of antihypertensive agents on intraocular and blood pressure in the rabbit. Albrecht v. Graefes Arch. klin. exp. Ophthal. 183, 179–195 (1971).

    Google Scholar 

  • Schulz, W., Zwieten, P. A. van: The influence of drugs that change blood pressure on intraocular pressure in the anaesthetized rat. Albrecht v. Graefes Arch. klin. exp. Ophthal. 180, 290 (1971).

    Google Scholar 

  • Sears, M. L., Sherk, T. E.: The trabecular effect of noradrenaline in the rabbit eye. Invest. Ophthal. 3, 157 (1964).

    Google Scholar 

  • Trendelenburg, U., Muskus, A., Fleming, W. W., Gomez Alonso de la Sierra, B.: Effect of cocaine, denervation and decentralization on the response of the nictitating membrane to various sympathetic amines. J. Pharmacol. exp. Ther. 138, 181 (1962).

    Google Scholar 

  • —, Weiner, N.: Sensitivity of the nictitating membrane after various procedures and agents. J. Pharmacol. exp. Ther. 136, 152 (1962).

    Google Scholar 

  • Wessely, K.: Experimentelle Untersuchungen über Augendruck sowie über qualitative Beeinflussung des intraokulären Flüssigkeitswechsels. Arch. Augenheilk. 60, 1, 97 (1908).

    Google Scholar 

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Authors and Affiliations

  1. Dept. of Pharmacology, Christian-Albrechts-University, Kiel, W.-Germany

    Regine Berroth &  P. A. van Zwieten

  2. Department of Biopharmacy, University of Amsterdam, Roeterstraat 1, Amsterdam-C, The Netherlands

    P. A. van Zwieten

Authors
  1. Regine Berroth
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  2. P. A. van Zwieten
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Berroth, R., van Zwieten, P.A. The influence of catecholamines on the normal and sympathetically decentralized rabbit eye. Albrecht von Graefes Arch. Klin. Ophthalmol. 183, 196–202 (1971). https://doi.org/10.1007/BF00412824

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  • DOI: https://doi.org/10.1007/BF00412824

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