Summary
A significant decrease of serum prealbumin levels and an increased proportion of prealbumin bearing lymphocytes in peripheral blood have been found in patients of hapten-induced diseases. Prealbumin deposition in the vessel walls, and/or prealbumin positive cells (granulocytes, lymphocytes, macrophages) in the dermis have been observed in patients with proved drug allergy as well as allergic contact dermatitis using immunofluorescence technique. The eluates from membrane of lymphocytes of patients with drug allergy contained a mitogenic substance, probably antigen and sometimes prealbumin as well. These results also support the earlier suggested hypothesis that the prealbumin may act as a hapten carrier protein.
Zusammenfassung
Die Verfasser fanden bei Hapten-bedingten Krankheiten den Präalbumingehalt im Serum verringert und die relative Zahl der Präalbumin-tragenden Lymphocyten erhöht. Ihre immunfluorescenzmikroskopischen Untersuchungen ließen bei allergischer Kontaktdermatitis- und Arzneimittelallergie-Patienten in den Gefäßwänden Präalbuminablagerung und in der Dermis Präalbumin-positive Entzündungszellen (Granulocyten, Lymphocyten, Makrophagen) feststellen. Bei arzneimittelallergischen Patienten konnte von der Membran der Lymphocyten ein mitogen wirksames Agens, offenbar ein Antigen, eluiert werden, welches in einigen Fällen auch Präalbumin enthielt. Diese neueren Befunde unterstützen ebenfalls die frühere Hypothese der Autoren von der Hapten-tragenden Rolle des Präalbumins.
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This work was supported by the Scientific Research Council, Ministry of Health, Hungary (Code No. 4-21-0304-01-1/S)
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Husz, S., Hunyadi, J., Dobozy, A. et al. Prealbumin as a hapten carrier protein in certain varieties of dermatitis. Arch Dermatol Res 264, 357–364 (1979). https://doi.org/10.1007/BF00412665
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DOI: https://doi.org/10.1007/BF00412665