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HLA-antigens in systemic lupus erythematosus (SLE)

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Summary

Histocompatibility antigens were determined in 27 patients with SLE and 283 normal blood donors. HLA-B8 was significantly increased in patients with SLE (59.3%) as compared to the controls (20.5% P c<0.005). The relative risk for HLA-B8 was 5.64. No correlation could be demonstrated to specific organ involvement, immunopathological data, age of onset or prognosis.

Zusammenfassung

Die Histokompatibilitätsantigene von 27 Patienten mit SLE und 283 normalen Blutspendern wurden bestimmt. HLA-B8 war bei Patienten mit LED (59,3%) signifikant erhöht gegenüber den Kontrollen (20,5%, P c<0,005). Das relative Risiko für HLA-B8 betrug 5,64. Mit spezifischen Organbeteiligungen, immunpathologischen Daten, dem Manifestationsalter oder der Prognose fand sich keine Korrelation.

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Authors and Affiliations

  1. Department of Internal Medicine, Free University of Berlin, Klinikum Charlottenburg, Spandauer Damm 130, D-1000, Berlin 19

    Dieter Kampf, Reinhard Malchus, Meta Alexander & Immo Hoppe

  2. Blood Center, Free University of Berlin, Klinikum Charlottenburg, Spandauer Damm 130, D-1000, Berlin 19

    Dieter Kampf, Reinhard Malchus, Meta Alexander & Immo Hoppe

Authors
  1. Dieter Kampf
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  2. Reinhard Malchus
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  3. Meta Alexander
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  4. Immo Hoppe
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Kampf, D., Malchus, R., Alexander, M. et al. HLA-antigens in systemic lupus erythematosus (SLE). Arch Dermatol Res 264, 345–350 (1979). https://doi.org/10.1007/BF00412663

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