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Experimentelle Uveitis bei der Ratte

Abhängigkeit der Uveaerkrankungen von der Zusammensetzung des Freundschen Adjuvans

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Zusammenfassung

Es werden die verschiedenen Formen der experimentellen Uveitis besprochen, und unter besonderer Berücksichtigung der letzten 20 Jahre wird eine Anzahl Versuche verschiedener Autoren erwähnt. Dann wird über eigene neue Experimente mit Ratten berichtet. Nach einer einmaligen subcutanen Injektion von Freundschem Adjuvans erkrankte ein Teil der Tiere an Polyarthritis und eine kleinere Zahl gleichzeitig oder einige Tage später an Uveitis mit deutlichen klinischen Symptomen. Uveitiden traten fast nur bei Tieren mit Polyarthritis auf. Es wurden zwei verschiedene Tuberkelbakterienstämme verwendet, von denen sich nur der eine als wirksam erwies. Einige durchgeführte Modifikationen des Experimentes beeinflußten die Resultate nicht eindeutig. Die Versuche stellen im allgemeinen eine Bestätigung der 1960 von Waksman beschriebenen Experimente dar.

Summary

The different forms of experimental uveitis are mentioned with special reference to works done by different authors in the last 20 years. Further are discussed our own recent experiments with rats. After a single subcutaneous injection of adjuvant a great majority of the animals showed polyarthritis and a small number of them developped uveitis with all its clinical manifestations. Of the two different strains of tubercle bacilli used, only one has been prooved to be effective. In spite of a few modifications of the experiments conducted the results remained more or less the same.

The results of these experiments confirm those of Waksman in 1960.

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  1. Universitäts-Augenklinik Zürich, Schweiz

    Verena Meier

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Meier, V. Experimentelle Uveitis bei der Ratte. Albrecht von Graefes Arch. Klin. Ophthalmol. 173, 293–308 (1967). https://doi.org/10.1007/BF00412646

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