Summary
Three different in vitro assays for the demonstration of circulating immune complexes were compared in 49 patients with psoriasis. Granulocytes from psoriatic subjects contained immune complex-like material in 25 patients (51%). When psoriatic serum was incubated with granulocytes from healthy blood donors, phagocytosed material was found in 18 patients (37%). The Raji-cell assay was only positive in two of 27 subjects (7%). Of the patients 71% tested positively with one of the granulocyte phagocytosis tests. Both tests were positive simultaneously in 16% and negative in 29% of the patients. The pathogenetic significance of the immune complex-like material is unclear.
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Lindholm, L., Mobacken, H. & Magnusson, B.L. Circulating immune complexes in untreated psoriasis. Arch Dermatol Res 279, 435–438 (1987). https://doi.org/10.1007/BF00412587
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DOI: https://doi.org/10.1007/BF00412587