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The effect of an oral therapeutic single-dose of griseofulvin on polymorphonuclear leukocyte migration in a casein gradient

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Summary

In a previous study, polymorphonuclear (PMN) leukocyte chemotaxis in vitro was inhibited by therapeutic concentrations of griseofulvin. In the present investigation, PMN migration in a casein gradient was studied in a cell suspension containing serum collected before and after a therapeutic peroral single-dose of griseofulvin. The PMN migration in vitro was not influenced significantly by the presence of griseofulvin-containing serum. It is suggested that peroral griseofulvin treatment has neglibible effect on PMN chemotaxis in vitro.

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Authors and Affiliations

  1. Department of Internal Medicine, Finspang Hospital, S-901 85, Umea, Sweden

    U. Bandmann

  2. Department of Dermatology, University Hospital, S-901 85, Umea, Sweden

    O. Bäck

  3. Department of Internal Medicine, University Hospital, S-901 85, Umea, Sweden

    B. Norberg

Authors
  1. U. Bandmann
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  2. O. Bäck
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  3. B. Norberg
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Bandmann, U., Bäck, O. & Norberg, B. The effect of an oral therapeutic single-dose of griseofulvin on polymorphonuclear leukocyte migration in a casein gradient. Arch Dermatol Res 276, 41–44 (1984). https://doi.org/10.1007/BF00412561

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  • DOI: https://doi.org/10.1007/BF00412561

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